What makes this antibody unique for research?

This antibody is specially designed to target and bind with high affinity to the transferrin receptor. Its unique construction allows it to specifically interfere with iron uptake pathways, making it invaluable for research in cellular metabolism and oncology.

Can this product be utilized in clinical settings?

No, this antibody is designed solely for research purposes. It provides essential data for pre-clinical explorations but is not approved for therapeutic or clinical use as it requires extensive further verification.

Anti-Human TfR Recombinant Antibody (3GH7 )

CAT#: TAB-628CT

Recombinant monoclonal antibody has the highest affinity for the TfR. This antibody can be potentially used in treating various human cancers and diseases that express transferrin receptor. It can inhibit the binding of Tf to the TfR.

Tested Data Gene Expression

SDS-PAGE

Figure 1 Anti-Human TfR Recombinant Antibody (TAB-628CT) in SDS-PAGE

Lane M: Protein Marker
Lane 1: Reducing (2.0ug)

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Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg

Normal Tissue Figure 5 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg

Normal Tissue Figure 7 Bone marrow

Hematopoietic cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg

Normal Tissue Figure 8 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC

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Specifications

Host Species
Human

Derivation
Human antibody phage display library

Type
Human antibody

Specificity
Human

Species Reactivity
Human

Clone
3GH7

Applications
Used for immunoassay techniques such as: Western Blot

Related Disease
Bladder cancer, colon cancer, prostate cancer, and pancreatic cancer

Target

Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90; CD71); anti-CD71

Gene ID
7037

UniProt ID
P02786

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Breast cancer biomarkers at key points during disease progression

Integral for Cancer Studies

This Anti-TfR antibody has been integral to our ongoing cancer research. Its precision in binding to transferrin receptors allows for accurate study of cellular processes, significantly contributing to our understanding of tumor biology.

Reliable and High-Quality Results

The consistency and robustness of this antibody have led to high-quality results time after time. It delivers dependable performance across different assays, proving its value and supporting the credibility of our research findings.

Q&As

What makes this antibody unique for research?

A: This antibody is specially designed to target and bind with high affinity to the transferrin receptor. Its unique construction allows it to specifically interfere with iron uptake pathways, making it invaluable for research in cellular metabolism and oncology.
Can this product be utilized in clinical settings?

A: No, this antibody is designed solely for research purposes. It provides essential data for pre-clinical explorations but is not approved for therapeutic or clinical use as it requires extensive further verification.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-628CT, RRID: AB_3111981)

Copy citation

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-628CT.pdf

MSDS

MSDS - TAB-628CT.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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