Human Anti-VEGF Recombinant Antibody (clone B20-4) (CAT#: PABC-131)

Recombinant Human Antibody (B20-4) is capable of binding to VEGF, expressed in HEK293 cells. Expressed as the combination of a heavy chain (HC) containing VH from antiVEGF mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from antiVEGF mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody binds and blocks both human and murine vascular endothelial growth factor (VEGF).


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 binding of G6-31 and B20-4.1 as IgG (10 μg/ml) to ELISA wells coated with VEGF homologues is shown.

Figure 1 binding of G6-31 and B20-4.1 as IgG (10 μg/ml) to ELISA wells coated with VEGF homologues is shown.

Liang, W. C., Wu, X., Peale, F. V., Lee, C. V., Meng, Y. G., Gutierrez, J., ... & Fuh, G. (2006). Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. Journal of Biological Chemistry, 281(2), 951-961.


Specifications

  • Immunogen
  • Human Vascular endothelial growth factor
  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human VEGF
  • Species Reactivity
  • Human, Mouse
  • Clone
  • B20-4
  • Applications
  • ELISA, Neut, Block

Product Property

  • Purification
  • Protein A/G Purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • See the COA
  • Buffer
  • PBS
  • Storage
  • Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Neutralization, Blocking.

Target

  • Alternative Names
  • Vascular endothelial growth factor; VEGF

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Humanized Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-288CQ Human Anti-VEGF Recombinant Antibody (TAB-288CQ) ELISA Chimeric (Mouse/Human) IgG1, κ
TAB-301CQ Human Anti-VEGF Recombinant Antibody (TAB-301CQ) ELISA, FC, IHC, WB Chimeric (Mouse/Human) IgG1, κ
TAB-301CQ-S(P) Human Anti-VEGF Recombinant Antibody; scFv Fragment (TAB-301CQ-S(P)) ELISA, FC, IHC, WB Human scFv
TAB-288CQ-F(E) Human Anti-VEGF Recombinant Antibody; Fab Fragment (TAB-288CQ-F(E)) ELISA, WB, IHC, Block Chimeric (Mouse/Human) Fab
TAB-301CQ-F(E) Human Anti-VEGF Recombinant Antibody; Fab Fragment (TAB-301CQ-F(E)) ELISA, FC, IHC, WB Chimeric (Mouse/Human) Fab

Fc Glycosylation

CAT Product Name Application Type
Gly-096LC Recombinant Anti-Human VEGF Antibody (Fc glycosylation) ELISA Humanized antibody
Gly-143LC Recombinant Anti-Human VEGF Antibody (Fc glycosylation) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-179LC Recombinant Anti-Human VEGF Antibody (Non-glycosylated) ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4485 Rabbit Anti-VEGF Recombinant Antibody (clone SI581DS) ELISA Rabbit IgG

Single-domain Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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