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    SmartAb™ Recombinant Anti-VEGF pH-dependent Antibody (Clone 4D3)

    CAT#: VS-0825-YC353

    The anti-VEGF pH-dependent antibody (clone 4D3) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human VEGF. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for VEGF under acidic conditions compared to physiological pH. Using a yeast surface display system with a pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from VEGF at pH 6.0. This pH-sensitive antibody retains its binding affinity on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human VEGF (Vascular Endothelial Growth Factor) is a signaling protein and the master regulator of angiogenesis. It is a key mediator of tumor growth and is a major therapeutic target for a variety of cancers.

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG
    • Specificity
    • Human VEGF
    • Species Reactivity
    • Human
    • Clone
    • 4D3
    • Applications
    • ELISA, Inhib

    Product Property

    • Clonality
    • Monoclonal
    • Purification
    • Protein A purified
    • Purity
    • >95%, determined by SDS-PAGE and SEC-HPLC
    • Buffer
    • PBS, pH 7.4
    • Preservative
    • No preservatives
    • Storage
    • For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.

    Target

    • Alternative Names
    • VEGF; Vascular endothelial growth factor
    • Long Name
    • Vascular endothelial growth factor
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    Related Diseases

    Bladder Cancer Bladder Cancer
    Rheumatoid Arthritis Rheumatoid Arthritis

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0825-YC353.pdf

    MSDS

    MSDS - VS-0825-YC353.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    See other products for "Clone 4D3"

    • CAT
    • Product Name

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