Anti-mesothelin ADC

Name: Anti-mesothelin ADC
SKU: ADC-126LZY
Rating: 5 (1 reviews)

CAT#: ADC-126LZY

This ADC product is in Phase I clinical trials and has demonstrated a response in Ovarian tumour, pancreatic tumour treatment.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg

Normal Tissue Figure 2 Fallopian tube

Ciliated cells (cilia axoneme)
Staining:

High

Intensity: Strong

Ciliated cells (tip of cilia)
Staining:

High

Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN

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Specifications

Antibody Overview
Humanized Anti-MSLN IgG1

Antibody Isotype
IgG1

Target

Introduction
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Alternative Names
MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor;

Gene ID
10232

UniProt ID
Q13421

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Downloadable Resources

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Datasheet

Datasheet - ADC-126LZY.pdf

MSDS

MSDS - ADC-126LZY.pdf

COA

Certificate of Analysis Lookup

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MOB-1165z	Mouse Anti-MSLN Recombinant Antibody (clone 44C3)	WB, ELISA, IHC	Mouse IgG2a

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PSBL-652	Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009); scFv Fragment	WB	Mouse scFv

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TAB-0833CL	Human Anti-MSLN Recombinant Antibody (TAB-0833CL)	ELISA, FuncS, Activ, FC	Human IgG1

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CAT	Product Name	Application	Type
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TAB-0834CL-S(P)	Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0834CL-S(P))	ELISA, FC	Human scFv

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MOB-1467MZ	Recombinant Mouse Anti-Human MSLN Antibody (clone L2)	FC, IHC-Fr, WB	Mouse antibody

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BRD-0376MZ	Chicken Anti-MSLN Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
MOR-2302	Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB)	WB	IgG

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HPAB-0041-CN	Mouse Anti-MSLN Recombinant Antibody (HPAB-0041-CN)	FC, WB, ELISA	Mouse IgG

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HPAB-0042-CN	Mouse Anti-MSLN Recombinant Antibody (HPAB-0042-CN)	FC, WB, ELISA	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0041-CN-S(P)	Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0041-CN-S(P))	FC, WB, ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0042-CN-S(P)	Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0042-CN-S(P))	FC, WB, ELISA	Mouse scFv

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HPAB-0043-CN-S(P)	Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0043-CN-S(P))	FC, WB, ELISA	Mouse scFv

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HPAB-0045-CN-S(P)	Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0045-CN-S(P))	FC, WB, ELISA	Human scFv

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HPAB-0041-CN-F(E)	Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0041-CN-F(E))	FC, WB, ELISA	Mouse Fab

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HPAB-0042-CN-F(E)	Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0042-CN-F(E))	FC, WB, ELISA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0043-CN-F(E)	Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0043-CN-F(E))	FC, WB, ELISA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0044-CN-F(E)	Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0044-CN-F(E))	FC, WB, ELISA	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-201	Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201)	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
MHC-CN0101	APC-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer	FCM

CAT	Product Name	Application	Type
MHC-CN0102	PE-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer	FCM

CAT	Product Name	Application	Type
MHC-CN1049	PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
MHC-CN1050	APC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
MHC-CN1051	FITC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
HPAB-M0391-YC	Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0391-YC)	ELISA, FC, IF	Llama VHH

CAT	Product Name	Application	Type
HPAB-M0392-YC	Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0392-YC)	ELISA, FC, IF	Llama VHH

CAT	Product Name	Application	Type
VS-0325-FY69	Human Anti-MSLN (clone SS) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC539	Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4533	Anti-MSLN Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY4534	Anti-Mouse MSLN Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY4535	Anti-Rat MSLN Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0825-YC258	SmartAb™ Recombinant Anti-MSLN pH-dependent Antibody (VS-0825-YC258)	ELISA, IF, IHC, IP, FC, Neut	Human IgG1 kappa

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