Anti-mesothelin Antibody-Cytokine Fusion Protein, IL12-scFv (SS1) (CAT#: ACFP-SH061)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-mesothelin scFv to the C terminus of the p35 subunit of IL12 through a short linker (GSADGG). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the mesothelin as well as the biological activity of IL12. The immunocytokine retained sufficient bioactivity of IL12 and significantly inhibited human malignant mesothelioma (NCI-H226) grown in the peritoneal cavity of nude mice and showed comparable anti-tumor activity to that of the SS1P immunotoxin. This immunocytokine was designed for treating mesothelin-positive tumors.

(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg

(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Specifications
- Target
- mesothelin
- Molecule Class
- IL12-scFv
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- SS1
- Related Disease
- Mesothelin-positive tumors
- Cytokine 1
- IL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor
- Gene ID
- 10232
- UniProt ID
- Q13421
Downloads
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HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0391-YC) | ELISA, FC, IF | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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