BV421-H2-K1/Human INS (LYLVCGERGF) MHC Tetramer (CAT#: MHC-LC985)

• Allele
• H2-K1

• Class
• Class I

• MHC Species
• Mouse

• Antigen
• INS

• Antigen Species
• Human

• Peptide
• LYLVCGERGF

• Range
• 39-48

• Conjugate
• BV421

• Application
• FCM

• Antigen Introduction
• After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

• Alternative Names
• INS; insulin; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10

• Gene ID
• 3630

• UniProt ID
• P01308

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