BV421-H2-K1/Human INS (LYLVCGERGF) MHC Tetramer (CAT#: MHC-LC985)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of INS-derived peptide of LYLVCGERGF covering 39-48 and H2-K1 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Normal Tissue
RNA Expression
Figure 1 Pancreas
(Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
(Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
Specifications
- Allele
- H2-K1
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- INS
- Antigen Species
- Human
- Peptide
- LYLVCGERGF
- Range
- 39-48
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- INS; insulin; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
Related Resources
Maturity Onset Diabetes of the Young
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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