CI-2 scaffold protein anti-Human Mdm-2
CAT#: SCI-L062
The CI-2 that bound Mdm-2 was isolated from the library using Rational design techonology. After affinity maturation, CI-2 variants were identified having affinities for Mdm-2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/1999_F7_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong nuclear positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/37938_A_6_7_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/170698_A_2_7_selected.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_3.jpg
Normal Tissue
Figure 8 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_4.jpg
Normal Tissue
Figure 9 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Pancreatic endocrine cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_2_3.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_5.jpg
Normal Tissue
Figure 11 Testis
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Peritubular cells
Staining: High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_5_6.jpg
Normal Tissue
Figure 12 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_8.jpg
RNA Expression
Figure 13 RNA cell line category: Cell line enhanced (HBEC3-KT, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135679-MDM2
❮
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Specifications
- Scaffold Name
- CI-2
- Origin
- CI-2
- Core Structure
- α/β (64)
- Variable Regions
- Peptide grafting
- Target
- Mdm-2
- Species Reactivity
- Human
- Expression Host
- HB2151
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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Related Diseases
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Related Signaling Pathways
p53 Signaling Pathway
Downloadable Resources
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COA
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|---|---|---|---|
| MOB-648-F(E) | Recombinant Anti-human MDM2 Antibody Fab Fragment | WB, FACS, FuncS | Fab |
| MHH-648-F(E) | Recombinant Human Anti-human MDM2 Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-648-S(P) | Recombinant Anti-human MDM2 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-648-S(P) | Recombinant Human Anti-human MDM2 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0353MZ | Chicken Anti-MDM2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4642 | Hi-Affi™ Recombinant Rabbit Anti-MDM2 Monoclonal Antibody (TH155DS) | WB, IF, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1420 | PE-A*02:01/Human MDM2 (LLGDLFGV) MHC Tetramer | FCM | |
| MHC-YF287 | A*02:01/Human MDM2 (LLGDLFGV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0396U | Rabbit Anti-MDM2 Recombinant Antibody (clone E22-L) | IHC-P | Rabbit IgG |
| VS3-FY917 | Recombinant Mouse Anti-MDM2 Antibody (clone 3C1E3) | ELISA, IHC, FC | Mouse IgG2b |
| VS3-FY918 | Recombinant Mouse Anti-MDM2 Antibody (clone 4A8D12) | ELISA, FC | Mouse IgG1 |
| VS3-FY919 | Recombinant Rabbit Anti-MDM2 (phospho Ser166) Antibody (clone R08-8C7) | WB, IHC-P | Rabbit IgG |
| VS3-WK2255 | Rabbit Anti-MDM2 (pS166) Recombinant Antibody (VS3-WK2255) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4322 | Anti-MDM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4323 | Anti-Human MDM2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-FY8 | Mouse Anti-MDM2 scFv-Fc Chimera (VS-0625-FY8) | ELISA, WB | Mouse IgG1, scFv-Fc |
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