Mouse Anti-MDM2 scFv-Fc Chimera (VS-0625-FY8) (CAT#: VS-0625-FY8)

• Immunogen
• The human MDM2 protein.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• Human MDM2

• Species Reactivity
• Human

• Applications
• ELISA, Western Blot

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• MDM2 Proto-Oncogene; MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase; Oncoprotein Mdm2; Hdm2; Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse); Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein; Mouse Double Minute 2, Human Homolog Of; P53-Binding Protein; Double Minute 2, Human Homolog Of; P53-Binding Protein; Mdm2, P53 E3 Ubiquitin Protein Ligase Homolog; MDM2 Oncogene, E3 Ubiquitin Protein Ligase

• Gene ID
• 4193

• UniProt ID
• Q00987

• Long Name
• MDM2 Proto-Oncogene

• Sequence Similarities
• Belongs to the MDM2/MDM4 family.

• Cellular Localization
• Nucleus, nucleoplasm; Cytoplasm; Nucleus

• Post Translation Modifications
• Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53.
  Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation.

• Protein Refseq
• XP_047284809.1; XP_054228034.1; XP_054228035.1; NP_001138809.1; NP_001138811.1

• Function
• E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526).
  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
  Also acts as a ubiquitin ligase E3 toward itself and ARRB1.
  Permits the nuclear export of p53/TP53.

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