PE-A*02:01/Human CD59 (SLSEKTVLL) MHC Tetramer

Name: PE-A*02:01/Human CD59 (SLSEKTVLL) MHC Tetramer
SKU: MHC-LC1980
Rating: 5 (1 reviews)

CAT#: MHC-LC1980

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CD59 of peptide SLSEKTVLL covering 106-114 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/279_B8_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows distinct membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/ihc_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line PC-3

Immunofluorescent staining of human cell line PC-3 shows localization to the vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/1432_F1_2_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/280_B8_1_blue_red_green.jpg

Normal Tissue Figure 5 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55053_B_8_5.jpg

Normal Tissue Figure 6 Colon

Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_7_3.jpg

Normal Tissue Figure 7 Urinary bladder

Urothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_6_5.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085063-CD59

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Specifications

Allele
A*02:01

Class
Class I

MHC Species
Human

Antigen
CD59

Antigen Species
Human

Peptide
SLSEKTVLL

Range
106-114

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Alternative Names
CD59; CD59 glycoprotein precursor; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20

Gene ID
966

UniProt ID
P13987

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Datasheet

Datasheet - MHC-LC1980.pdf

MSDS

MSDS - MHC-LC1980.pdf

COA

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