Anti-Human CD59 Recombinant Antibody (HV2/KV3)
CAT#: TAB-323LC
This product is a monoclonal antibody against CD59. This is a humanized antibody that could potentially be used to treat prostate, breast and lung cancer. CD59 is an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein expressed in a variety of normal and cancer tissues.
Published Data
Gene Expression
ELISA
Figure 1 demonstrates the binding of humanized variants, chimeric and murine AR36A36.11.1 to the human breast cancer cell line MDA-MB-231.
Cyt
Figure 2 demonstrates the in vitro CDC activity of murine and humanized variants of AR36 A36.11.1 on the human breast cancer cell line MD A-MB-231.
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Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/279_B8_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows distinct membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to the vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/1432_F1_2_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/280_B8_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55053_B_8_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_7_3.jpg
Normal Tissue
Figure 7 Urinary bladder
Urothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_6_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085063-CD59
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- HV2/KV3
- Applications
- Cyt, ELISA
- Related Disease
- Prostate cancer, Breast cancer, Lung cancer
Applications
- Application Notes
- This antibody has been reported for use in Cytotoxicity, Enzyme-linked Immunosorbent Assay.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone HV2/KV3"
- CAT
- Product Name
See other products for "CD59"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1088z | Mouse Anti-CD59 Recombinant Antibody (clone 18C6) | FC, IF, FuncS | Mouse IgM, κ |
| MRO-0311-CN | Rabbit Anti-CD59 Recombinant Antibody (clone JM10-71) | WB, IF, FC, IP | Rabbit IgG |
| FAMAB-1074CQ | Mouse Anti-CD59 Recombinant Antibody (clone YTH 53.1) | FC | Mouse IgG1 |
| VS3-XY382 | Mouse Anti-CD59 Recombinant Antibody (clone 8D2B8) | ELISA, WB, IHC, FC, ICC | Mouse IgG1 |
| VS11-QX41 | Mouse Anti-CD59 Recombinant Antibody (clone 193-27) | FC, IHC, IF | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-317LC | Mouse Anti-CD59 Recombinant Antibody (TAB-317LC) | WB, ELISA | Mouse IgG1 |
| TAB-318LC | Anti-Human CD59 Recombinant Antibody (1E8) | ELISA, FC | |
| TAB-320LC | Anti-Human CD59 Recombinant Antibody (AR36A36.11.1) | ELISA, WB, FC | |
| TAB-317LC-F(E) | Mouse Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-317LC-F(E)) | WB, ELISA | Mouse Fab |
| TAB-318LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment (1E8) | FC, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-319LC | Human Anti-CD59 Recombinant Antibody (TAB-319LC) | ELISA, FC, Inhib | Human IgG1 |
| TAB-319LC-S(P) | Human Anti-CD59 Recombinant Antibody; scFv Fragment (TAB-319LC-S(P)) | ELISA | Human scFv |
| TAB-319LC-F(E) | Human Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-319LC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-321LC | Anti-Human CD59 Recombinant Antibody ((ch)AR36A36.11.1) | ELISA, FuncS, WB | Chimeric antibody (mouse/human) |
| TAB-321LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment ((ch)AR36A36.11.1) | WB, ELISA | Chimeric antibody (mouse/human) |
| TAB-321LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) | WB, ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-322LC | Anti-Human CD59 Recombinant Antibody (HV3/KV3 ) | Cyt, ELISA | Humanized antibody |
| TAB-322LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment (HV3/KV3 ) | WB, ELISA | Humanized antibody |
| TAB-322LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment (HV3/KV3 ) | WB, ELISA | Humanized antibody |
| TAB-323LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment (HV2/KV3) | WB, ELISA | Humanized antibody |
| TAB-324LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment (HV2/KV4) | WB, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-397CQ | Mouse Anti-CD59 Recombinant Antibody (clone MEM-43) | Neut, FC, IHC, IHC-P, IP, CyTOF® | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-398CQ | Rat Anti-CD59 Recombinant Antibody (clone YTH53.1) | Block, FC, ICC, IF, IHC-Fr, IHC-P, WB, FuncS | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0572 | Hi-Affi™ Rabbit Anti-CD59 Recombinant Antibody (clone DS572AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1953 | PE-A2/Human CD59 (SLSEKTVLL) MHC Tetramer | FCM | |
| MHC-LC1980 | PE-A*02:01/Human CD59 (SLSEKTVLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1325 | AbPlus™ Anti-Cd59 Magnetic Beads (VS-0724-YC1325) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY58 | Human Anti-CD59 (clone 1E8) scFv-Fc Chimera | ELISA, FC, CDC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY62 | CytoStream™ Mouse Anti-CD59 Recombinant Antibody (clone MEM-43) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY368 | Anti-CD59 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1204 | Anti-Mouse CD59 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1203 | Anti-Human CD59 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC183 | Recombinant Anti-CD59 Vesicular Antibody, EV Displayed (VS-0425-YC183) | ELISA, FC, Cell-uptake |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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