PE-A2/Human CD59 (SLSEKTVLL) MHC Tetramer (CAT#: MHC-LC1953)

• Allele
• A2

• Class
• Class I

• MHC Species
• Human

• Antigen
• CD59

• Antigen Species
• Human

• Peptide
• SLSEKTVLL

• Range
• 106-114

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD59; CD59 glycoprotein precursor; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20

• Gene ID
• 966

• UniProt ID
• P13987

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