Recombinant monoclonal antibody to CD59. (ch)AR36A36.11.1 is a chimeric antibody (mouse/human) that can be potentially used in the treatment of prostate cancer, breast cancer and lung cancer.
Figure 1 demonstrates the effect of AR36 A36.11.1 on tumor growth in an established human PC-3 prostate cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 2 demonstrates the effect of AR36A36.11.1 on tumor growth in an established human breast MDA-MB-468 cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 3 demonstrates the effect of AR36A36.11.1 in a dose-response manner on tumor growth in an established human breast (MDA-MB-231) cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 4 demonstrates effect of AR36A36.11.1 on mouse survival in a prophylactic NCI-H520 human lung squamous cell carcinoma model. Data points represent the survival percentage.
Figure 5 Western blot of a total membrane preparation of MDA-MB-231 breast cancer cells probed with different primary antibody solutions.
Lanes 3 to 7 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated AR36A36.11.1 respectively. Lanes 9-13 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated 10 A304.7 respectively. Lanes 15-19 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated 8BlB.1 respectively.
Figure 6 demonstrates the binding of humanized variants, chimeric and murine AR36A36.11.1 to the human breast cancer cell line MDA-MB-231.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1088z | Mouse Anti-CD59 Recombinant Antibody (clone 18C6) | FC, IF, FuncS | Mouse IgM, κ |
MOB-0520CT | Recombinant Mouse anti-Human CD59 Monoclonal antibody (2G6) | FC | |
MRO-0311-CN | Rabbit Anti-CD59 Recombinant Antibody (clone JM10-71) | WB, IF, FC, IP | Rabbit IgG |
FAMAB-1074CQ | Mouse Anti-CD59 Recombinant Antibody (clone YTH 53.1) | FC | Mouse IgG1 |
ZG-0208U | Mouse Anti-CD59 Recombinant Antibody (clone 2E11B6) | ELISA, WB, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-317LC | Mouse Anti-CD59 Recombinant Antibody (TAB-317LC) | WB, ELISA | Mouse IgG1 |
TAB-318LC | Anti-Human CD59 Recombinant Antibody (1E8) | ELISA, FC | |
TAB-320LC | Anti-Human CD59 Recombinant Antibody (AR36A36.11.1) | ELISA, WB, FC | |
TAB-317LC-F(E) | Mouse Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-317LC-F(E)) | WB, ELISA | Mouse Fab |
TAB-318LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment (1E8) | FC, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-319LC | Human Anti-CD59 Recombinant Antibody (TAB-319LC) | ELISA, FC, Inhib | Human IgG1 |
TAB-319LC-S(P) | Human Anti-CD59 Recombinant Antibody; scFv Fragment (TAB-319LC-S(P)) | ELISA | Human scFv |
TAB-319LC-F(E) | Human Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-319LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-322LC | Anti-Human CD59 Recombinant Antibody (HV3/KV3 ) | Cyt, ELISA | Humanized antibody |
TAB-323LC | Anti-Human CD59 Recombinant Antibody (HV2/KV3) | Cyt, ELISA | Humanized antibody |
TAB-322LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment (HV3/KV3 ) | WB, ELISA | Humanized antibody |
TAB-323LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment (HV2/KV3) | WB, ELISA | Humanized antibody |
TAB-324LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment (HV2/KV4) | WB, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-321LC-S(P) | Anti-Human CD59 Recombinant Antibody scFv Fragment ((ch)AR36A36.11.1) | WB, ELISA | Chimeric antibody (mouse/human) |
TAB-321LC-F(E) | Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) | WB, ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-397CQ | Mouse Anti-CD59 Recombinant Antibody (clone MEM-43) | Neut, FC, IHC, IHC-P, IP, CyTOF® | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-398CQ | Rat Anti-CD59 Recombinant Antibody (clone YTH53.1) | Block, FC, ICC, IF, IHC-Fr, IHC-P, WB, FuncS | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0572 | Hi-Affi™ Rabbit Anti-CD59 Recombinant Antibody (clone DS572AB) | WB, IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1953 | PE-A2/Human CD59 (SLSEKTVLL) MHC Tetramer | FCM | |
MHC-LC1980 | PE-A*02:01/Human CD59 (SLSEKTVLL) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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