Anti-Human CD59 Recombinant Antibody ((ch)AR36A36.11.1) (CAT#: TAB-321LC)

Recombinant monoclonal antibody to CD59. (ch)AR36A36.11.1 is a chimeric antibody (mouse/human) that can be potentially used in the treatment of prostate cancer, breast cancer and lung cancer.


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  • Published Data
  • Gene Expression
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  • MSDS
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FuncS

Figure 1 demonstrates the effect of AR36 A36.11.1 on tumor growth in an established human PC-3 prostate cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

Figure 1 demonstrates the effect of AR36 A36.11.1 on tumor growth in an established human PC-3 prostate cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 2 demonstrates the effect of AR36A36.11.1 on tumor growth in an established human breast MDA-MB-468 cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

Figure 2 demonstrates the effect of AR36A36.11.1 on tumor growth in an established human breast MDA-MB-468 cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 3 demonstrates the effect of AR36A36.11.1 in a dose-response manner on tumor growth in an established human breast (MDA-MB-231) cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

Figure 3 demonstrates the effect of AR36A36.11.1 in a dose-response manner on tumor growth in an established human breast (MDA-MB-231) cancer model. The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 4 demonstrates effect of AR36A36.11.1 on mouse survival in a prophylactic NCI-H520 human lung squamous cell carcinoma model. Data points represent the survival percentage.

Figure 4 demonstrates effect of AR36A36.11.1 on mouse survival in a prophylactic NCI-H520 human lung squamous cell carcinoma model. Data points represent the survival percentage.

WB

Figure 5 Western blot of a total membrane preparation of MDA-MB-231 breast cancer cells probed with different primary antibody solutions.

Figure 5 Western blot of a total membrane preparation of MDA-MB-231 breast cancer cells probed with different primary antibody solutions.

Lanes 3 to 7 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated AR36A36.11.1 respectively. Lanes 9-13 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated 10 A304.7 respectively. Lanes 15-19 were probed with biotinylated AR36A36.11.1 mixed with 0.5 micrograms/mL, 5 micrograms/mL, 50 micrograms/mL, 500 micrograms/mL and 1000 micrograms/mL of non-biotinylated 8BlB.1 respectively.

ELISA

Figure 6 demonstrates the binding of humanized variants, chimeric and murine AR36A36.11.1 to the human breast cancer cell line MDA-MB-231.

Figure 6 demonstrates the binding of humanized variants, chimeric and murine AR36A36.11.1 to the human breast cancer cell line MDA-MB-231.


Specifications

  • Host Species
  • Human
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Chimeric antibody (mouse/human)
  • Specificity
  • Human
  • Clone
  • (ch)AR36A36.11.1
  • Applications
  • ELISA, FuncS, WB
  • Related Disease
  • Prostate cancer, Breast cancer, Lung cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Western Blot.

Target

  • Alternative Names
  • 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; C59

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone (ch)AR36A36.11.1"

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Chimeric Antibody

CAT Product Name Application Type
TAB-321LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment ((ch)AR36A36.11.1) WB, ELISA Chimeric antibody (mouse/human)
TAB-321LC-F(E) Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) WB, ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-397CQ Mouse Anti-CD59 Recombinant Antibody (clone MEM-43) Neut, FC, IHC, IHC-P, IP, CyTOF® Mouse IgG2a

Blocking Antibody

CAT Product Name Application Type
NEUT-398CQ Rat Anti-CD59 Recombinant Antibody (clone YTH53.1) Block, FC, ICC, IF, IHC-Fr, IHC-P, WB, FuncS Rat IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0572 Hi-Affi™ Rabbit Anti-CD59 Recombinant Antibody (clone DS572AB) WB, IHC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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