PE-B*53:01/Human FOLH1 (LPSIPVHPI) MHC Tetramer
CAT#: MHC-LC2505
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human FOLH1 of peptide LPSIPVHPI covering 289-297 and B*53:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
❮
❯
Specifications
- Allele
- B*53:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- FOLH1
- Antigen Species
- Human
- Peptide
- LPSIPVHPI
- Range
- 289-297
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
- Alternative Names
- FOLH1; Glutamate carboxypeptidase 2; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase
- Gene ID
- 2346
- UniProt ID
- Q04609
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Datasheet
MSDS
COA
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