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Anti-Human CCR2 Recombinant Antibody (Plozalizumab) (CAT#: TAB-444CQ)

Recombinant monoclonal antibody to CCR2. Plozalizumab is a humanized monoclonal antibody that can be potentially used in the treatment of Atherosclerosis, Diabetic nephropathies, Malignant melanoma. It binds to CCR2 and prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2.


See more Engineered Antibody products for CCR2
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Subcellular Location
Figure 1 IF staining of human cell line THP-1
Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63255/1926_C6_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cervix, uterine
Figure 2 IHC staining of human cervix, uterine
(Immunohistochemical staining of human cervix, uterine shows strong cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/ihc_selected.jpg
Figure 3 Cervix
Figure 3 Cervix
(Squamous epithelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_B_8_3.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
Figure 5 RNA cell line category: Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000121807-CCR2

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • IgG1, κ
  • Specificity
  • Human CCR2
  • Species Reactivity
  • Human
  • Applications
  • Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry; Inhibition
  • Conjugate
  • Unconjugated
  • CAS
  • 1610761-46-0
  • Generic Name
  • Plozalizumab
  • UNII
  • 4XG66BMN0D
  • Related Disease
  • Atherosclerosis, Diabetic nephropathies, Malignant melanoma

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • Chemokine (C-C Motif) Receptor 2; Monocyte Chemoattractant Protein 1 Receptor; CC-CKR-2; MCP-1-R; CMKBR2; CCR-2; Monocyte Chemotactic Protein 1 Receptor; MCP-1 Receptor; CD192 Antigen; C-C CKR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CKR2

Related Resources

  • Biosimilar Overview
Please refer to Plozalizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Plozalizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Plozalizumab"

Afuco™ Anti-CCR2 ADCC Recombinant Antibody (Plozalizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CCR2. Plozalizumab is a humanized monoclonal antibody that can be potentially used in the treatment of Atherosclerosis, Diabetic nephropathies, Malignant melanoma. It binds to CCR2 and prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2.

See other products for "CCR2"

scFv Fragment Antibody

CAT Product Name Application Type
MOB-159-S(P) Recombinant Anti-human CCR2 Antibody scFv Fragment ELISA, WB, FuncS scFv
MHH-159-S(P) Recombinant Human Anti-human CCR2 Antibody scFv Fragment WB, IHC, FuncS scFv
HPAB-0247-YC-S(P) Human Anti-CCR2 Recombinant Antibody; scFv Fragment (HPAB-0247-YC-S(P)) ELISA, FC Human scFv
HPAB-0248-YC-S(P) Human Anti-CCR2 Recombinant Antibody; scFv Fragment (HPAB-0248-YC-S(P)) ELISA, FC Human scFv
HPAB-1571WJ-S(P) Human Anti-CCR2 Recombinant Antibody; scFv Fragment (clone hu1D9) ELISA, WB Human scFv

Recombinant Antibody

CAT Product Name Application Type
MHH-159 Recombinant Human Anti-human CCR2 Antibody WB, IP, FuncS IgG
MOB-0368CT Mouse Anti-CCR2 Recombinant Antibody (clone 59708.232) FC Mouse IgG2b
HPAB-0247-YC Human Anti-CCR2 Recombinant Antibody (HPAB-0247-YC) ELISA, FC Human IgG4
HPAB-0248-YC Human Anti-CCR2 Recombinant Antibody (HPAB-0248-YC) ELISA, FC Human IgG4
HPAB-0249-YC Human Anti-CCR2 Recombinant Antibody (HPAB-0249-YC) ELISA, FC Human IgG4

Fab Fragment Antibody

CAT Product Name Application Type
MHH-159-F(E) Recombinant Human Anti-human CCR2 Antibody Fab Fragment FC, WB, FuncS Fab
HPAB-0247-YC-F(E) Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0247-YC-F(E)) ELISA, FC Human Fab
HPAB-0248-YC-F(E) Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0248-YC-F(E)) ELISA, FC Human Fab
HPAB-0249-YC-F(E) Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0249-YC-F(E)) ELISA, FC Human Fab
HPAB-0250-YC-F(E) Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0250-YC-F(E)) ELISA, FC Human Fab

Humanized Antibody

CAT Product Name Application Type
TAB-099CL Anti-Human CCR2 Recombinant Antibody (MLN1202) FuncS Antibody

Human Antibody

CAT Product Name Application Type
TAB-1511CL Human Anti-CCR2 Recombinant Antibody (TAB-1511CL) ELISA Human IgG
TAB-1512CL Human Anti-CCR2 Recombinant Antibody (TAB-1512CL) ELISA Human IgG
TAB-1513CL Human Anti-CCR2 Recombinant Antibody (TAB-1513CL) ELISA Human IgG
TAB-1514CL Human Anti-CCR2 Recombinant Antibody (TAB-1514CL) ELISA, FuncS Human IgG
TAB-1515CL Human Anti-CCR2 Recombinant Antibody (TAB-1515CL) ELISA, FuncS Human IgG

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0096MZ Chicken Anti-CCR2 Polyclonal IgY WB Chicken antibody
BRD-0127MZ Chicken Anti-CKR2 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0520 Hi-Affi™ Rabbit Anti-CCR2 Recombinant Antibody (clone DS520AB) WB, FC, IP, IHC-Fr, IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-444CQ Afuco™ Anti-CCR2 ADCC Recombinant Antibody (Plozalizumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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