Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated)
CAT#: Gly-139LC
This product is a non-fucosylated human monoclonal antibody. The antibody Defuc-5F11 with enhanced ADCC specficfically binds to human CD30 and can be potentially used in the treatment of lymphomas cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Subcellular Location
Figure 4 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Subcellular Location
Figure 5 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Subcellular Location
Figure 6 IF staining of human cell line K-562
Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Normal Tissue
Figure 8 Appendix
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
❮
❯
Glyco-engineering
- Glycosylation site
- Asn297 in Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Enhanced ADCC
Specifications
- Target
- CD30 (Cluster of differentiation-30)
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Antibody Isotype
- IgG
- Clone
- Defuc-5F11
- Expression Host
- CHO DG44
- Applications
- ELISA
Target
- Alternative Names
- TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;
- Related Disease
- Lymphomas cancers
- Gene ID
- 943
- UniProt ID
- A5D8T4
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Datasheet
MSDS
COA
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Lot Number:
See other products for "Clone Defuc-5F11"
- CAT
- Product Name
See other products for "TNFRSF8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-144 | Anti-Human CD30 Recombinant Antibody (Iratumumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-153 | Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G062E | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G062R | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G062S | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap | Cytotoxicity assay, Function study | |
| AGTO-L041E | anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L041R | anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CL | Human Anti-TNFRSF8 Recombinant Antibody (TAB-635CL) | ELISA | Human IgG |
| TAB-103LC | Anti-Human TNFRSF8 Recombinant Antibody | WB, FC, ELISA | Humanized antibody |
| TAB-103LC-S(P) | Anti-Human TNFRSF8 Recombinant Antibody scFv Fragment | WB, FC, ELISA | Humanized antibody |
| TAB-103LC-F(E) | Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment | WB, FC, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-139LC-1 | Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0597MZ | Chicken Anti-TNFRSF8 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2165CQ | Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) | FC, Stim, Costim, Block | Hamster IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2166CQ | Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) | Neut, FC | Hamster IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3617 | Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3617AB) | WB, IHC-P | Rabbit IgG |
| MOR-3618 | Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3618AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0329-YC | Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0329-YC) | ELISA, FC, Cyt, FuncS, Inhib | Mouse IgG |
| HPAB-0330-YC | Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0330-YC) | ELISA, FC, Cyt, FuncS, Inhib | Chimeric (mouse/human) IgG1, κ |
| HPAB-0331-YC | Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0331-YC) | ELISA, FC, Cyt, FuncS, Inhib | Mouse IgG |
| HPAB-0332-YC | Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0332-YC) | FC, Cyt, FuncS | Human IgG1, κ |
| HPAB-0333-YC | Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0333-YC) | FC, Cyt, FuncS | Human IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0329-YC-S(P) | Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0329-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-0330-YC-S(P) | Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0330-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-0331-YC-S(P) | Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0331-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-0332-YC-S(P) | Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0332-YC-S(P)) | FC, Cyt | Human scFv |
| HPAB-0250-FY-S(P) | Recombinant Human Anti-TNFRSF8 Antibody scFv Fragment | F, IH | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0445-CN-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105); Fab Fragment | WB, ELISA, FC | Mouse Fab |
| HPAB-0447-CN-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-0325CQ-F(E) | Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0325CQ-F(E)) | ELISA, FC, FuncS, Cyt | Humanized Fab |
| HPAB-0326CQ-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ki-4); Fab Fragment | Inhib, ELISA, FC, IF, IHC | Mouse Fab |
| FAMAB-0358WJ-F(E) | Human Anti-TNFRSF8 Recombinant Antibody (clone AK30); Fab Fragment | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-144 | Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-144) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-153 | Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-153) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY50 | Mouse Anti-TNFRSF8 Agonistic Antibody (VS-0724-XY50) | WB, FC, Agonistic assays, CyTOF® | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY77 | Human Anti-TNFRSF8 (clone Iratumumab) scFv-Fc Chimera | ELISA, FC, IP, FuncS, IF, Neut | Human IgG1, scFv-Fc |
| VS-0325-FY13 | Human Anti-TNFRSF8 scFv-Fc Chimera (VS-0325-FY13) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY223 | CytoStream™ Armenian Hamster Anti-TNFRSF8 Recombinant Antibody (VS-0225-XY223) | FC | Armenian Hamster IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC248 | Recombinant Anti-TNFRSF8 Vesicular Antibody, EV Displayed (VS-0425-YC248) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7385 | Anti-TNFRSF8 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC181 | Recombinant Anti-TNFRSF8 (Ep2 x Ep7) Biparatopic Antibody, Tandem scFv (Clone T215 x Clone T408) | ELISA, FC, WB | Tandem scFv |
| VS-0525-YC183 | Recombinant Anti-TNFRSF8 (AA 107-153 x AA 282-338) Biparatopic Antibody, Tandem scFv (Clone T105 x Clone T405) | ELISA, WB | Tandem scFv |
| VS-0525-YC234 | Recombinant Anti-TNFRSF8 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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