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TNFRSF8

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Anti-TNFRSF8 Products

    • Target: CD30
    • Drug: human pro-apoptotic effector protein, microtubule-associated protein tau (MAPT)
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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
TNFRSF8
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