TNFRSF8
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0333-YC) (HPAB-0333-YC)
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- Species Reactivity: Human
- Type: Human IgG, κ
- Application: FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T215) (HPAB-0334-YC)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, WB
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- Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0330-YC) (HPAB-0330-YC)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1, κ
- Application: ELISA, FC, Cyt, FuncS, Inhib
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405) (HPAB-0447-CN)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ki-4) (HPAB-0326CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, FC, IP, FuncS, IF, Neut
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: Neut, ELISA, IF, IP, FuncS, FC
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ber-H2) (HPAB-0090-YJ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC, IF, FC
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- Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0459-WJ) (HPAB-0459-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FuncS
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- Recombinant Human Anti-TNFRSF8 Antibody (HPAB-0250-FY)
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: Human IgG1
- Application: F, IH
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105) (HPAB-0445-CN)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC
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- Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0325CQ) (HPAB-0325CQ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, FuncS, Cyt
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- Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0331-YC) (HPAB-0331-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, Cyt, FuncS, Inhib
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- Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0332-YC) (HPAB-0332-YC)
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0329-YC) (HPAB-0329-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, Cyt, FuncS, Inhib
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T408) (HPAB-0335-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, FC, WB
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- Anti-Human TNFRSF8 Recombinant Antibody (TAB-103LC)
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- Derivation: Humanized
- Type: Humanized antibody
- Application: WB, FC, ELISA
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- Anti-Human TNFRSF8 Recombinant Antibody scFv Fragment (TAB-103LC-S(P))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: WB, FC, ELISA
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- Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment (TAB-103LC-F(E))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: WB, FC, ELISA
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- Target: CD30
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: scFv-Fc-IL12
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- Target: CD30
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: scFv-Fc-IL2
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- Target: CD30
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: scFv-IL2
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- Target: CD30
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Human
- Cytokine 1 Species: Mouse
- Molecule Class: scFv-IL12
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- Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA (AGTO-G062R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap (AGTO-G062S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE (AGTO-L041E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE (AGTO-G062E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA (AGTO-L041R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap (AGTO-L041S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0329-YC-S(P)) (HPAB-0329-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Cyt, FuncS
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- Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0330-YC-S(P)) (HPAB-0330-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0331-YC-S(P)) (HPAB-0331-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Cyt, FuncS
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- Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0332-YC-S(P)) (HPAB-0332-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Cyt
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- Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0333-YC-S(P)) (HPAB-0333-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T215); scFv Fragment (HPAB-0334-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T408); scFv Fragment (HPAB-0335-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB
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- Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0329-YC-F(E)) (HPAB-0329-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Cyt, FuncS
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- Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0330-YC-F(E)) (HPAB-0330-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0331-YC-F(E)) (HPAB-0331-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Cyt, FuncS
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- Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0332-YC-F(E)) (HPAB-0332-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, Cyt
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- Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0333-YC-F(E)) (HPAB-0333-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, Cyt, FuncS
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T215); Fab Fragment (HPAB-0334-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T408); Fab Fragment (HPAB-0335-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405); scFv Fragment (HPAB-0447-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA
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- Target: CD30
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Human
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
- Molecule Class: scFv-IL12-IL2
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105); scFv Fragment (HPAB-0445-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC
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- Recombinant Human Anti-TNFRSF8 Antibody scFv Fragment (HPAB-0250-FY-S(P))
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: Human scFv
- Application: F, IH
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- Recombinant Human Anti-TNFRSF8 Antibody Fab Fragment (HPAB-0250-FY-F(E))
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: Human Fab
- Application: F, IH
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- Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0459-WJ-F(E)) (HPAB-0459-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0325CQ-F(E)) (HPAB-0325CQ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, FuncS, Cyt
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- Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ki-4); Fab Fragment (HPAB-0326CQ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib, ELISA, FC, IF, IHC
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- Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0325CQ-S(P)) (HPAB-0325CQ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, FuncS, Cyt
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- Target: CD30
- Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
- Drug: MMAE (Monomethyl auristatin E)
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- Chicken Anti-TNFRSF8 Polyclonal IgY (BRD-0597MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Anti-CD30 (clone cAc10)-vc-PABC-MMAE ADC (ADC-064LZY)
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- Target: CD30
- Linker: VC-PABC(valine-citrulline-p-aminobenzylcarbamate)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-CD30 monoclonal antibody (MDX-1401) (Gly-009CL)
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Non fucosylated
- Glycosylation site: Asn297 in Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Non fucosylated
- Glycosylation site: Asn297 in Fc region
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- Anti-CD30-DBCO-MMAF ADC (ADC-301CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30-DBCO-MMAF ADC (ADC-302CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30-DBCO-MMAF ADC (ADC-303CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30-DBCO-MMAF ADC (ADC-304CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (brentuximab)-DIBO-doxorubicin ADC (ADC-038LCT)
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- Target: CD30
- Linker: DIBO (dibenzylcyclooctynol)
- Drug: doxorubicin
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- Anti-CD30-DBCO-MMAF ADC (ADC-305CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (cAC10)-vcMMAE ADC (ADC-039LCT)
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- Target: CD30
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30-DBCO-MMAF ADC (ADC-306CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (cAC10)-MC-PABC-MMAE ADC (ADC-040LCT)
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- Target: CD30
- Linker: MC-PABC (maleimidocaproyl-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30 (cAC10)-mc-vc-MMAE ADC (ADC-041LCT)
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- Target: CD30
- Linker: mc-VC (maleimidocaproyl-valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30-DBCO-MMAF ADC (ADC-312CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (clone cAC10)-vc-MMAE ADC (ADC-024LZY)
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- Target: CD30
- Linker: VC (valine-citrulline)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-CD30 (cAC10)-MC-VC-PABC-MMAE ADC (ADC-042LCT)
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- Target: CD30
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30-DBCO-MMAF ADC (ADC-313CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (cAC10)-vc-MMAF ADC (ADC-043LCT)
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- Target: CD30
- Linker: VC (valine-citrulline)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30-DBCO-MMAF ADC (ADC-314CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (clone cAC10)-vc-PAB-MMAE ADC (ADC-008LZY)
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- Target: CD30
- Linker: VC-PAB (valine-citrulline with PAB)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-CD30 (cAC10)-vc-PABC-MMAE ADC (ADC-044LCT)
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- Target: CD30
- Linker: VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30-DBCO-MMAF ADC (ADC-315CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (cAC10)-DIBO-doxorubicin ADC (ADC-124LCT)
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- Target: CD30
- Linker: DIBO (dibenzylcyclooctynol)
- Drug: doxorubicin
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- Anti-CD30 (hCA10)-α-glucuronide-MMAE ADC (ADC-045LCT)
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- Target: CD30
- Linker: α-glucuronide
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30-DBCO-MMAF ADC (ADC-316CL)
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- Target: CD30
- Linker: DBCO (Dibenzocyclooctyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (clone cAC10)-mc-vc-PABC-MMAE ADC (ADC-156LZY)
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- Target: CD30
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-CD30 (hCA10)-α-glucuronide-MMAF ADC (ADC-046LCT)
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- Target: CD30
- Linker: α-glucuronide
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (CA10)-β-glucuronide-MMAE ADC (ADC-049LCT)
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- Target: CD30
- Linker: β-glucuronide linker
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD30 (cCA10)-β-glucuronide-MMAF ADC (ADC-050LCT)
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- Target: CD30
- Linker: β-glucuronide linker
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 (Ki4) scFv-MAP ADC (ADC-052LCT)
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- Target: CD30
- Drug: human pro-apoptotic effector protein, microtubule-associated protein tau (MAPT)
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- Anti-CD30 receptorc (AC10)-mc-MMAF ADC (ADC-054LCT)
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- Target: CD30 receptor
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD30 receptorc (AC10)-mc-vc-PABC-MMAF ADC (ADC-055LCT)
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- Target: CD30 receptor
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAF (Monomethyl auristatin F)
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
