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TNFRSF8

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DBCO (Dibenzocyclooctyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
DIBO (dibenzylcyclooctynol)
Drug:
doxorubicin
Target:
CD30
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD30
Linker:
MC-PABC (maleimidocaproyl-p-aminobenzoyloxycarbonyl)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD30
Linker:
mc-VC (maleimidocaproyl-valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD30
Linker:
MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD30
Linker:
VC (valine-citrulline)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD30
Linker:
VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug:
MMAE (Monomethyl auristatin E)
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