Recombinant Anti-TNFRSF8 (AA 107-153 x AA 282-338) Biparatopic Antibody, Tandem scFv (Clone T105 x Clone T405) (CAT#: VS-0525-YC183)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Human TNFRSF8

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• T105

• Clone 2
• T405

• Epitope 1
• aa 107-153 of CD30

• Epitope 2
• aa 282-338 of CD30

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, WB

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• TNF Receptor Superfamily Member 8

• Introduction
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• Alternative Names
• CD30; Ki-1; D1S166E

• Gene ID
• 943

• UniProt ID
• P28908

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