Recombinant Anti-TNFRSF8 (AA 107-153 x AA 282-338) Biparatopic Antibody, Tandem scFv (Clone T105 x Clone T405)
CAT#: VS-0525-YC183
This biparatopic antibody (bpAb) targets two distinct epitopes of TNFRSF8. Its tandem scFv design involves the N-terminal fusion of the T105 scFv (specific for amino acids 107-153 of CD30) to the T405 scFv (recognizing amino acids 282-338 of CD30).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Subcellular Location
Figure 4 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Subcellular Location
Figure 5 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Subcellular Location
Figure 6 IF staining of human cell line K-562
Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Normal Tissue
Figure 8 Appendix
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Human TNFRSF8
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- T105
- Clone 2
- T405
- Epitope 1
- aa 107-153 of CD30
- Epitope 2
- aa 282-338 of CD30
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- TNF Receptor Superfamily Member 8
Target
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- Alternative Names
- CD30; Ki-1; D1S166E
- Gene ID
- 943
- UniProt ID
- P28908
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0330-YC-S(P) | Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0330-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
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| HPAB-0332-YC-S(P) | Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0332-YC-S(P)) | FC, Cyt | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0329-YC-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0329-YC-F(E)) | ELISA, FC, Cyt, FuncS | Mouse Fab |
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| HPAB-0332-YC-F(E) | Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0332-YC-F(E)) | FC, Cyt | Human Fab |
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