1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA (CAT#: AGTO-G062R)

    This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF8 overexpressed malignant lymphoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of malignant lymphoma.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HDLM-2
    Figure 1 IF staining of human cell line HDLM-2
    (Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
    Figure 2 IHC staining of human testis
    Figure 2 IHC staining of human testis
    (Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
    Figure 3 IHC staining of human tonsil
    Figure 3 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
    Figure 4 IHC staining of human tonsil
    Figure 4 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
    Figure 5 IF staining of human cell line EFO-21
    Figure 5 IF staining of human cell line EFO-21
    (Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
    Figure 6 IF staining of human cell line K-562
    Figure 6 IF staining of human cell line K-562
    (Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
    Normal Tissue
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
    Figure 8 Appendix
    Figure 8 Appendix
    (Glandular cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Clone
    • Ki-3
    • Molecule Class
    • scFv-RTA
    • Toxin Description
    • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • lymphoma

    Target

    • Alternative Names
    • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone Ki-3"

    See other products for "TNFRSF8"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Human Antibody Products Chimeric Antibody Products Immunotoxin Products Humanized Antibody Products Fc Glycosylation Antibody Products Low- or Non-fucosylated Oligosaccharide Antibody Products Chicken IgY Antibody Products Blocking Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products Agonistic Antibody Products ScFv-Fc Chimera Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    MOB-1158z Mouse Anti-TNFRSF8 Recombinant Antibody (clone 19C10) WB, FC, FuncS Mouse IgG2b
    HPAB-0329-YC Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0329-YC) ELISA, FC, Cyt, FuncS, Inhib Mouse IgG
    HPAB-0330-YC Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0330-YC) ELISA, FC, Cyt, FuncS, Inhib Chimeric (mouse/human) IgG1, κ
    HPAB-0250-FY Recombinant Human Anti-TNFRSF8 Antibody F, IH Human IgG1
    HPAB-0090-YJ Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ber-H2) IHC, IF, FC Mouse IgG1, κ

    Customer Reviews and Q&As

    Submit a review or a question

    There are currently no Customer reviews or questions for AGTO-G062R. Click the button above to contact us or submit your feedback about this product.

    Popular products with customers

    Figure 1 Recombinant Anti-5-FU Antibody (MOB-12) in ELISA

    Recombinant Anti-5-FU Antibody (CAT# MOB-12)
    Application: WB, Neut, FuncS

    Figure 2 Anti-CTLA4 Antibody (TAB-067) in ELISA

    Anti-Human CTLA4 Recombinant Antibody (TAB-067) (CAT# TAB-067)
    Application: WB, FuncS, IF, Neut, ELISA, FC, IP

    Figure 2 Anti-Human EGFR Recombinant Antibody (TAB-020) in ELISA

    Anti-Human EGFR Recombinant Antibody (Panitumumab) (CAT# TAB-020)
    Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

    Figure 2 Anti-Human 4-1BB Therapeutic Antibody (TAB-179) in Dot Blot

    Anti-Human 4-1BB Recombinant Antibody (TAB-179) (CAT# TAB-179)
    Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

    Figure 10 Blockade of PD-1/PD-L1 interaction by anti-PD-1 antibody (Cat# TAB-770) resulted in an increase of IFN-γ production.

    Anti-PDCD1 Recombinant Antibody (TAB-770) (CAT# TAB-770)
    Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

    Figure 4 Anti-Human IL1 beta Recombinant Antibody (TAB-161) in ELISA

    Anti-Human IL1 beta Recombinant Antibody (TAB-161) (CAT# TAB-161)
    Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

    Figure 4 Anti-Human IAV HA Recombinant Antibody (TAB-705)-Fc silenced in ELISA

    Anti-αvβ3 Integrin Recombinant Antibody (TAB-705) (CAT# TAB-705)
    Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

    Figure 2 Recombinant Anti-HIV env Antibody (PABL-179) in HPLC

    Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128) (CAT# PABL-179)
    Application: WB, ELISA, FuncS

    Figure 2 Human TIM3 Recombinant Antibody (TAB-0366CL) in WB

    Anti-Human TIM3 Recombinant Antibody (TSR-022) (CAT# TAB-0366CL)
    Application: FC, FuncS

    Figure 2 Anti-NCR3LG1 Recombinant Antibody (TAB-1134CL) in SEC-HPLC

    Mouse Anti-NCR3LG1 Recombinant Antibody (TAB-1134CL) (CAT# TAB-1134CL)
    Application: ELISA

    Figure 2 Anti-Mouse TIGIT Recombinant Antibody (TAB-0279CL) in HPLC

    Hamster Anti-TIGIT Recombinant Antibody (TAB-0279CL) (CAT# TAB-0279CL)
    Application: FuncS

    Figure 3 Anti-CD33 Antibody (TAB-119LC) in DB

    Mouse Anti-CD33 Recombinant Antibody (TAB-119LC) (CAT# TAB-119LC)
    Application: ELISA, IF, RIA

    Figure 3 Anti-Human CEACAM6 Recombinant Antibody (TAB-444LC) in DB

    Anti-Human CEACAM6 Recombinant Antibody (TAB-444LC) (CAT# TAB-444LC)
    Application: IHC, ELISA, FC, WB, ADCC, FuncS

    Figure 1 Mouse Anti-Collagen I (RGD motif) Recombinant Antibody (TAB-053MZ) in SDS-PAGE

    Mouse Anti-Collagen I (RGD motif) Recombinant Antibody (TAB-053MZ) (CAT# TAB-053MZ)
    Application: WB, IF, FuncS

    Figure 2 Anti-Human TEM7R Recombinant Antibody (TAB-577CT) in HPLC

    Human Anti-PLXDC2 Recombinant Antibody (TAB-577CT) (CAT# TAB-577CT)
    Application: ELISA, FC, IHC, IF

    Figure 2 Anti-Human TREM1 Recombinant Antibody (TAB-167CQ) in SDS-PAGE

    Human Anti-TREM1 Recombinant Antibody (TAB-167CQ) (CAT# TAB-167CQ)
    Application: ELISA, FC, WB, Block

    Figure 2 Anti-VEEV E2 Antibody (MRO-1164LC) in HPLC

    Anti-VEEV E2 Recombinant Antibody (Hy4-26A) (CAT# MRO-1164LC)
    Application: WB, ELISA

    Figure 2 Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) in HPLC

    Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) (CAT# HPAB-0344-CN)
    Application: WB, FC, Block

    Figure 2 Human IgG1, lambda Isotype Control Antibody (MOB-173CQ) in HPLC

    Human IgG1, lambda Isotype Control Antibody (CAT# MOB-173CQ)
    Application: ELISA

    Figure 3 Mouse Anti-Fibrin β chain Antibody (MOB-195YJL) in DB

    Mouse Anti-Fibrin β chain Recombinant Antibody (MOB-195YJL) (CAT# MOB-195YJL)
    Application: ELISA

    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

    Send Inquiry

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Go to compare

    Go to compare