TRX4 (CAT#: Gly-002CL)

TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.


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Specifications

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  • Small Molecule
  • Mechanism of action
  • TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.

References

  • Synonyms
  • Otelixizumab

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Mouse Antibody

CAT Product Name Application Type
TAB-0416CL Anti-Human CD3 Recombinant Antibody (OKT3) FC, IB, ELISA
TAB-0422CL Mouse Anti-CD3 Recombinant Antibody (TAB-0422CL) ELISA Mouse IgG
TAB-070LC Mouse Anti-CD3 Recombinant Antibody (TAB-070LC) ELISA Mouse IgG
TAB-073LC Mouse Anti-CD3 Recombinant Antibody (TAB-073LC) ELISA, FC Mouse IgG
TAB-074LC Mouse Anti-CD3 Recombinant Antibody (TAB-074LC) ELISA, FC Mouse IgG

Humanized Antibody

CAT Product Name Application Type
TAB-0418CL-S(P) Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA, FC, FuncS Humanized Antibody
TAB-0418CL-F(E) Humanized Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA, FC, FuncS Humanized Antibody
TAB-095LC Human Anti-CD3 Recombinant Antibody (TAB-095LC) FC, WB Human IgG1
TAB-096LC Human Anti-CD3 Recombinant Antibody (TAB-096LC) FC, WB Human IgG1
TAB-098LC Human Anti-CD3 Recombinant Antibody (TAB-098LC) ELISA, SPR Humanized IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-0417CL-F(E) Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA, FC, FuncS Chimeric (mouse/human)
TAB-071LC-S(P) Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-072LC-S(P) Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-071LC-F(E) Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)
TAB-072LC-F(E) Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)

Recombinant Antibody

CAT Product Name Application Type
MOB-0271MZ Mouse Anti-CD3 Recombinant Antibody (clone G8.2.38 (1).) IHC Mouse IgG1
MOB-049CQ Mouse Anti-CD3 Recombinant Antibody (clone CBLS-190) IP, IHC-P, FC, FuncS Mouse IgG1
MOB-108CQ Mouse Anti-CD3 Recombinant Antibody (MOB-108CQ) FC, Activ Mouse IgG2a
HPAB-0672LY Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) ELISA, FC Mouse IgG1
HPAB-0673LY Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) ELISA, FC Mouse IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-339CQ Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) FC, Block, IHC-Fr, IF, WB Mouse IgG2a
NEUT-340CQ Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block Mouse IgG1, κ

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0667LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) ELISA, FC Mouse Fab
HPAB-0668LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) ELISA, FC Mouse Fab
HPAB-0669LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) ELISA, FC Mouse Fab
HPAB-0670LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) ELISA, FC Mouse Fab
HPAB-0671LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0218-WJ-S(P) Human Anti-CD3 Recombinant Antibody (clone CD3B220); scFv Fragment ELISA, FC, IHC Humanized scFv
HPAB-0543-WJ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone YTH 12.5); scFv Fragment ELISA, FC Mouse scFv
HPAB-0544-WJ-S(P) Human Anti-CD3 Recombinant Antibody (clone HuYTH 12.5); scFv Fragment ELISA, FC Humanized scFv
HPAB-1526WJ-S(P) Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (clone 1D10) ELISA, WB, FC Mouse scFv
HPAB-1527WJ-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (clone h1D10) ELISA, WB, FC Human scFv

Single-domain Antibody

CAT Product Name Application Type
HPAB-M0378-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) ELISA, FC Llama VHH
HPAB-M0379-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) ELISA, FC Llama VHH
HPAB-1029WJ Recombinant Camelid Anti-CD3 Single Domain Antibody ELISA Camelid VHH

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