TRX4 (CAT#: Gly-002CL)

TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.


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Specifications

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  • Small Molecule
  • Mechanism of action
  • TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.

References

  • Synonyms
  • Otelixizumab

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Chimeric Antibody

CAT Product Name Application Type
TAB-0417CL Chimeric Anti-Human CD3 Recombinant Antibody ELISA, FC, FuncS Chimeric (mouse/human)
TAB-0417CL-S(P) Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA, FC, FuncS Chimeric (mouse/human)
TAB-0417CL-F(E) Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA, FC, FuncS Chimeric (mouse/human)
TAB-071LC-S(P) Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-072LC-S(P) Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)

Humanized Antibody

CAT Product Name Application Type
TAB-0418CL-S(P) Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA, FC, FuncS Humanized Antibody
TAB-0418CL-F(E) Humanized Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA, FC, FuncS Humanized Antibody
TAB-075LC-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-075LC-S(P)) ELISA Human scFv
TAB-076LC-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-076LC-S(P)) ELISA Human scFv
TAB-077LC-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-077LC-S(P)) ELISA Human scFv

Mouse Antibody

CAT Product Name Application Type
TAB-070LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-070LC-F(E)) ELISA Mouse Fab
TAB-073LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-073LC-F(E)) ELISA Mouse Fab
TAB-074LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-074LC-F(E)) ELISA Mouse Fab
TAB-097LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-097LC-F(E)) ELISA, SPR Mouse Fab
TAB-099LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-099LC-F(E)) ELISA, SPR Mouse Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-339CQ Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) FC, Block, IHC-Fr, IF, WB Mouse IgG2a
NEUT-340CQ Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block Mouse IgG1, κ

Recombinant Antibody

CAT Product Name Application Type
FAMAB-0053YC Mouse Anti-CD3 Recombinant Antibody (clone G3(3)) FC, IHC Mouse IgG
FAMAB-0043CQ Mouse Anti-CD3 Recombinant Antibody (clone 898H2-6-15) ELISA, FuncS Mouse IgG2a, κ
FAMAB-0044CQ Mouse Anti-CD3 Recombinant Antibody (clone FN18) ELISA, WB, FC, FuncS Mouse IgG, κ
HPAB-1793LY Human Anti-CD3 Recombinant Antibody (HPAB-1793LY) ELISA Human IgG
FN-205CQ Mouse Anti-CD3 Recombinant Antibody (clone CBL-1337) FC, FuncS, IHC, IF, IP Mouse IgG3, κ

Fab Fragment Antibody

CAT Product Name Application Type
FAMAB-0053-YC-F(E) Mouse Anti-CD3 Recombinant Antibody (clone G3(3)); Fab Fragment FC, IHC Mouse Fab
HPAB-0667LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) ELISA, FC Mouse Fab
HPAB-0668LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) ELISA, FC Mouse Fab
HPAB-0669LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) ELISA, FC Mouse Fab
HPAB-0670LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) ELISA, FC Mouse Fab

Single-domain Antibody

CAT Product Name Application Type
HPAB-M0378-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) ELISA, FC Llama VHH
HPAB-M0379-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) ELISA, FC Llama VHH
HPAB-1029WJ Recombinant Camelid Anti-CD3 Single Domain Antibody ELISA Camelid VHH

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0546-WJ-S(P) Human Anti-CD3 Recombinant Antibody (clone HuM291); scFv Fragment ELISA Humanized scFv
HPAB-0441-YJ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone m3E3); scFv Fragment ELISA, FC Mouse scFv
HPAB-0442-YJ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone hc3E3); scFv Fragment ELISA, FC Mouse scFv
HPAB-1526WJ-S(P) Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (clone 1D10) ELISA, WB, FC Mouse scFv
HPAB-1527WJ-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (clone h1D10) ELISA, WB, FC Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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