TRX4 (CAT#: Gly-002CL)
TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.
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Specifications
- Type
- Small Molecule
- Mechanism of action
- TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.
References
- Synonyms
- Otelixizumab
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Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-118CL | Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-118CL) | ELISA | Fab fragment |
| TAB-095LC | Human Anti-CD3 Recombinant Antibody (TAB-095LC) | FC, WB | Human IgG1 |
| TAB-096LC | Human Anti-CD3 Recombinant Antibody (TAB-096LC) | FC, WB | Human IgG1 |
| TAB-098LC | Human Anti-CD3 Recombinant Antibody (TAB-098LC) | ELISA, SPR | Humanized IgG |
| TAB-100LC | Human Anti-CD3 Recombinant Antibody (TAB-100LC) | ELISA, SPR | Humanized IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-0416CL | Anti-Human CD3 Recombinant Antibody (OKT3) | FC, IB, ELISA | |
| TAB-0422CL-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-0422CL-F(E)) | ELISA | Mouse Fab |
| TAB-097LC | Mouse Anti-CD3 Recombinant Antibody (TAB-097LC) | ELISA, SPR | Mouse IgG |
| TAB-099LC | Mouse Anti-CD3 Recombinant Antibody (TAB-099LC) | ELISA, SPR | Mouse IgG |
| TAB-070LC-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-070LC-F(E)) | ELISA | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-0417CL-S(P) | Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA, FC, FuncS | Chimeric (mouse/human) |
| TAB-0417CL-F(E) | Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA, FC, FuncS | Chimeric (mouse/human) |
| TAB-071LC | Anti-Human CD3 Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-072LC | Chimeric Anti-Human CD3 Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-071LC-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-339CQ | Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) | FC, Block, IHC-Fr, IF, WB | Mouse IgG2a |
| NEUT-340CQ | Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) | FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block | Mouse IgG1, κ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-049CQ | Mouse Anti-CD3 Recombinant Antibody (clone CBLS-190) | IP, IHC-P, FC, FuncS | Mouse IgG1 |
| MOB-108CQ | Mouse Anti-CD3 Recombinant Antibody (MOB-108CQ) | FC, Activ | Mouse IgG2a |
| HPAB-0672LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0673LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0674LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0674LY) | ELISA, FC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| FAMAB-0043CQ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone 898H2-6-15); scFv Fragment | FuncS | Mouse scFv |
| FAMAB-0044CQ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone FN18); scFv Fragment | WB, FC, FuncS | Mouse scFv |
| HPAB-1793LY-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-1793LY-S(P)) | ELISA | Human scfv |
| HPAB-0218-WJ-S(P) | Human Anti-CD3 Recombinant Antibody (clone CD3B220); scFv Fragment | ELISA, FC, IHC | Humanized scFv |
| HPAB-0441-YJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone m3E3); scFv Fragment | ELISA, FC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0667LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0668LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0669LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0670LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0671LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) | ELISA, FC | Mouse Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
| HPAB-M0378-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) | ELISA, FC | Llama VHH |
| HPAB-M0379-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) | ELISA, FC | Llama VHH |
| HPAB-1029WJ | Recombinant Camelid Anti-CD3 Single Domain Antibody | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot
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