TRX4 (CAT#: Gly-002CL)
TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.
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Specifications
- Type
- Small Molecule
- Mechanism of action
- TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.
References
- Synonyms
- Otelixizumab
Downloads
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See other products for "CD3"
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-0416CL | Anti-Human CD3 Recombinant Antibody (OKT3) | FC, IB, ELISA | |
| TAB-0422CL | Mouse Anti-CD3 Recombinant Antibody (TAB-0422CL) | ELISA | Mouse IgG |
| TAB-070LC | Mouse Anti-CD3 Recombinant Antibody (TAB-070LC) | ELISA | Mouse IgG |
| TAB-073LC | Mouse Anti-CD3 Recombinant Antibody (TAB-073LC) | ELISA, FC | Mouse IgG |
| TAB-074LC | Mouse Anti-CD3 Recombinant Antibody (TAB-074LC) | ELISA, FC | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-0418CL-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA, FC, FuncS | Humanized Antibody |
| TAB-0418CL-F(E) | Humanized Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA, FC, FuncS | Humanized Antibody |
| TAB-095LC | Human Anti-CD3 Recombinant Antibody (TAB-095LC) | FC, WB | Human IgG1 |
| TAB-096LC | Human Anti-CD3 Recombinant Antibody (TAB-096LC) | FC, WB | Human IgG1 |
| TAB-098LC | Human Anti-CD3 Recombinant Antibody (TAB-098LC) | ELISA, SPR | Humanized IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-0417CL-F(E) | Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA, FC, FuncS | Chimeric (mouse/human) |
| TAB-071LC-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-072LC-S(P) | Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-071LC-F(E) | Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-072LC-F(E) | Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-0271MZ | Mouse Anti-CD3 Recombinant Antibody (clone G8.2.38 (1).) | IHC | Mouse IgG1 |
| MOB-049CQ | Mouse Anti-CD3 Recombinant Antibody (clone CBLS-190) | IP, IHC-P, FC, FuncS | Mouse IgG1 |
| MOB-108CQ | Mouse Anti-CD3 Recombinant Antibody (MOB-108CQ) | FC, Activ | Mouse IgG2a |
| HPAB-0672LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0673LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) | ELISA, FC | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-339CQ | Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) | FC, Block, IHC-Fr, IF, WB | Mouse IgG2a |
| NEUT-340CQ | Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) | FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block | Mouse IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0667LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0668LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0669LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0670LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0671LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) | ELISA, FC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0218-WJ-S(P) | Human Anti-CD3 Recombinant Antibody (clone CD3B220); scFv Fragment | ELISA, FC, IHC | Humanized scFv |
| HPAB-0543-WJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone YTH 12.5); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0544-WJ-S(P) | Human Anti-CD3 Recombinant Antibody (clone HuYTH 12.5); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-1526WJ-S(P) | Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (clone 1D10) | ELISA, WB, FC | Mouse scFv |
| HPAB-1527WJ-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (clone h1D10) | ELISA, WB, FC | Human scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
| HPAB-M0378-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) | ELISA, FC | Llama VHH |
| HPAB-M0379-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) | ELISA, FC | Llama VHH |
| HPAB-1029WJ | Recombinant Camelid Anti-CD3 Single Domain Antibody | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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