TRX4 (CAT#: Gly-002CL)

TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.

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Specifications

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  • Small Molecule
  • Mechanism of action
  • TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.

References

  • Synonyms
  • Otelixizumab

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Humanized Antibody

CAT Product Name Application Type
TAB-118CL Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-118CL) ELISA Fab fragment
TAB-095LC Human Anti-CD3 Recombinant Antibody (TAB-095LC) FC, WB Human IgG1
TAB-096LC Human Anti-CD3 Recombinant Antibody (TAB-096LC) FC, WB Human IgG1
TAB-098LC Human Anti-CD3 Recombinant Antibody (TAB-098LC) ELISA, SPR Humanized IgG
TAB-100LC Human Anti-CD3 Recombinant Antibody (TAB-100LC) ELISA, SPR Humanized IgG

Mouse Antibody

CAT Product Name Application Type
TAB-0416CL Anti-Human CD3 Recombinant Antibody (OKT3) FC, IB, ELISA
TAB-0422CL-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-0422CL-F(E)) ELISA Mouse Fab
TAB-097LC Mouse Anti-CD3 Recombinant Antibody (TAB-097LC) ELISA, SPR Mouse IgG
TAB-099LC Mouse Anti-CD3 Recombinant Antibody (TAB-099LC) ELISA, SPR Mouse IgG
TAB-070LC-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-070LC-F(E)) ELISA Mouse Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-0417CL-S(P) Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA, FC, FuncS Chimeric (mouse/human)
TAB-0417CL-F(E) Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment ELISA, FC, FuncS Chimeric (mouse/human)
TAB-071LC Anti-Human CD3 Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-072LC Chimeric Anti-Human CD3 Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-071LC-S(P) Anti-Human CD3 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-339CQ Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) FC, Block, IHC-Fr, IF, WB Mouse IgG2a
NEUT-340CQ Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block Mouse IgG1, κ

Recombinant Antibody

CAT Product Name Application Type
MOB-049CQ Mouse Anti-CD3 Recombinant Antibody (clone CBLS-190) IP, IHC-P, FC, FuncS Mouse IgG1
MOB-108CQ Mouse Anti-CD3 Recombinant Antibody (MOB-108CQ) FC, Activ Mouse IgG2a
HPAB-0672LY Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) ELISA, FC Mouse IgG1
HPAB-0673LY Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) ELISA, FC Mouse IgG1
HPAB-0674LY Mouse Anti-CD3 Recombinant Antibody (HPAB-0674LY) ELISA, FC Mouse IgG1

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0043CQ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone 898H2-6-15); scFv Fragment FuncS Mouse scFv
FAMAB-0044CQ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone FN18); scFv Fragment WB, FC, FuncS Mouse scFv
HPAB-1793LY-S(P) Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-1793LY-S(P)) ELISA Human scfv
HPAB-0218-WJ-S(P) Human Anti-CD3 Recombinant Antibody (clone CD3B220); scFv Fragment ELISA, FC, IHC Humanized scFv
HPAB-0441-YJ-S(P) Mouse Anti-CD3 Recombinant Antibody (clone m3E3); scFv Fragment ELISA, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0667LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) ELISA, FC Mouse Fab
HPAB-0668LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) ELISA, FC Mouse Fab
HPAB-0669LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) ELISA, FC Mouse Fab
HPAB-0670LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) ELISA, FC Mouse Fab
HPAB-0671LY-F(E) Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) ELISA, FC Mouse Fab

Single-domain Antibody

CAT Product Name Application Type
HPAB-M0378-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) ELISA, FC Llama VHH
HPAB-M0379-YC Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) ELISA, FC Llama VHH
HPAB-1029WJ Recombinant Camelid Anti-CD3 Single Domain Antibody ELISA Camelid VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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