This human complement, component 5 (C5) specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities for human complement, component 5 (C5) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-901 | Anti-Human C5 Recombinant Antibody (Pexelizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | scFv |
TAB-1372CL | Human Anti-C5 Recombinant Antibody (TAB-1372CL) | Inhib, FuncS | Humanized antibody |
TAB-1373CL | Human Anti-C5 Recombinant Antibody (TAB-1373CL) | IB, CDC, Inhib | Humanized IgG |
TAB-1374CL | Human Anti-C5 Recombinant Antibody (TAB-1374CL) | ELISA, CDC, Inhib | Humanized IgG |
TAB-1375CL | Human Anti-C5 Recombinant Antibody (TAB-1375CL) | CDC, Inhib | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1366CL | Mouse Anti-C5 Recombinant Antibody (TAB-1366CL) | ELISA, Inhib | Mouse IgG |
TAB-1367CL | Mouse Anti-C5 Recombinant Antibody (TAB-1367CL) | ELISA, Inhib | Mouse IgG |
TAB-1368CL | Mouse Anti-C5 Recombinant Antibody (TAB-1368CL) | ELISA | Mouse IgG |
TAB-1366CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1366CL-S(P)) | ELISA, Inhib | Mouse scFv |
TAB-1367CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1367CL-S(P)) | ELISA, Inhib | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-082CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL249) | ELISA, Neut | Mouse IgG2a |
NEUT-083CQ | Mouse Anti-C5 Recombinant Antibody (clone MM0608-6H13) | ELISA, Neut, WB | Mouse IgG1 |
NEUT-084CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL030) | ELISA, WB, Neut | Mouse IgG1 |
NEUT-085CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL250) | ELISA, WB, IHC, FuncS | Mouse IgG1 |
NEUT-086CQ | Mouse Anti-C5 Recombinant Antibody (clone G25/2) | ELISA, IP, WB, Neut | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-088CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL771) | WB, Block, ELISA | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4104 | Hi-Affi™ Rabbit Anti-C5 Recombinant Antibody (clone SI175DS) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-453CQ | Anti-Human C5 Recombinant Antibody (Tesidolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ2 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0609-CN | Human Anti-C5 Recombinant Antibody (HPAB-0609-CN) | ELISA, Block | Humanized IgG |
HPAB-0611-CN | Rabbit Anti-C5 Recombinant Antibody (HPAB-0611-CN) | PK, SPR, IF, ELISA, WB, FC | Rabbit IgG |
HPAB-0612-CN | Human Anti-C5 Recombinant Antibody (HPAB-0612-CN) | PK, WB, ELISA, FC | Humanized IgG |
HPAB-0613-CN | Human Anti-C5 Recombinant Antibody (HPAB-0613-CN) | WB, ELISA, FC | Humanized IgG |
HPAB-0614-CN | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1) | Inhib, FuncS, WB, ELISA, IF, IP, Block | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0609-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0609-CN-F(E)) | ELISA, Block | Humanized Fab |
HPAB-0611-CN-F(E) | Rabbit Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0611-CN-F(E)) | WB, ELISA, FC | Rabbit Fab |
HPAB-0612-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0612-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
HPAB-0127CQ-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0127CQ-F(E)) | ELISA, WB, Inhib, FuncS | Human Fab |
HPAB-0128CQ-F(E) | Mouse Anti-C5 Recombinant Antibody (clone BB5.1); Fab Fragment | FC, FuncS, IA, IF, IP, IHC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-559 | Recombinant Llama Anti-C5 Single Domain Antibody (Nb36) | ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-453CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Tesidolumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-008 | Afuco™ Anti-C5 ADCC Recombinant Antibody (Eculizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-436CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Olendalizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0016-YC-S(P) | Rabbit Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-M0016-YC-S(P)) | ELISA | Rabbit scFv |
HPAB-M0017-YC-S(P) | Rabbit Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-M0017-YC-S(P)) | ELISA | Rabbit scFv |
HPAB-M0018-YC-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-M0018-YC-S(P)) | ELISA | Humanized scFv |
HPAB-1484-FY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-1484-FY-F(E)) | ELISA, Neut | Mouse Fab |
HPAB-1577WJ-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (clone 5G1.1) | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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