Z-domain of protein A scaffold protein anti-Human complement, component 5 (C5)
CAT#: SZA-L229
This human complement, component 5 (C5) specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities for human complement, component 5 (C5) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
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Specifications
- Scaffold Name
- Z-domain of protein A
- Origin
- Staphylococcal protein A
- Core Structure
- 3-α helixes
- Variable Regions
- 13 Residues on first and second helix surface
- Target
- Human complement, component 5 (C5)
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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Related Diseases
Systemic Lupus Erythematosus
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0611-CN-F(E) | Rabbit Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0611-CN-F(E)) | WB, ELISA, FC | Rabbit Fab |
| HPAB-0612-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0612-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
| HPAB-0613-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0613-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
| HPAB-0614-CN-F(E) | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1); Fab Fragment | WB, ELISA, IF, IP, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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