Anti-carbonic anhydrase 9 (CA-IX)-vc-MMAE ADC
CAT#: ADC-018LZY
This ADC product is composed of an anti-carbonic anhydrase 9 (CA-IX) antibody conjugated via vc linker to MMAE (anti-CA-IX-vc-MMAE). It is in phase I clinical trials and has demonstrated a response in solid tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 Immunofluorescent staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
Normal Tissue
Figure 2 Stomach
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
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Specifications
- Antibody Overview
- Human Anti-CA-IX IgG1
- Antibody Isotype
- IgG1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
- Alternative Names
- MN; CAIX
- Gene ID
- 768
- UniProt ID
- Q16790
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MSDS
COA
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|---|---|---|---|
| TAB-707 | Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-H43 | Anti-Human CA9 Recombinant Antibody (TAB-H43) | ELISA, IP, IF, Inhib | IgG1 - kappa |
| CAT | Product Name | Application | Type |
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| PSBZ-017 | Mouse Anti-CA9 Recombinant Antibody (clone M75); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-0104-LSX-S(P) | Human Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0104-LSX-S(P)) | ELISA | Human scFv |
| HPAB-0105-LSX-S(P) | Human Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0105-LSX-S(P)) | ELISA | Human scFv |
| HPAB-0355-CN-S(P) | Mouse Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0355-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-0356-CN-S(P) | Mouse Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0356-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1454CL-F(E) | Anti-Human CA9 Recombinant Antibody Fab Fragment (G250) | Cyt | |
| TAB-1455CL-F(E) | Anti-Human CA9 Recombinant Antibody Fab Fragment (S239D/I332E) | SPR | |
| TAB-1456CL-F(E) | Anti-Human CA9 Recombinant Antibody Fab Fragment (MSC1) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1457CL-F(E) | Anti-Human CA9 Recombinant Antibody Fab Fragment (MSC2) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1459CL-F(E) | Anti-Human CA9 Recombinant Antibody Fab Fragment (MSC4) | ELISA, FC, Inhib | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1458CL-F(E) | Anti-Human CA9 Recombinant Antibody (MSC3); Fab Fragment | FC | Human Fab |
| HPAB-0355-CN-F(E) | Mouse Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0355-CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| HPAB-0356-CN-F(E) | Mouse Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0356-CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| HPAB-1174WJ-F(E) | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.5.2); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1175WJ-F(E) | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.6.1); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0310CT | Mouse Anti-CA9 Recombinant Antibody (clone 3E4) | ELISA, FC, IF, IHC-P, WB | Mouse IgG1 |
| MRO-0229-CN | Rabbit Anti-CA9 Recombinant Antibody (clone CBACN-083) | WB, IHC | Rabbit IgG |
| ZG-0735F | Mouse Anti-CA9 Recombinant Antibody (clone 66.4.C2) | IHC-P, IHC-Fr | Mouse IgG2b |
| VS3-QX140 | Mouse Anti-CA9 Recombinant Antibody (clone 5B5-B10-A2) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK1020 | Mouse Anti-CA9 Recombinant Antibody (VS3-WK1020) | WB, IHC, IP | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC175 | PE-A*24:02/Human CA9 (EYRALQLHL) MHC Tetramer | FCM | |
| MHC-LC176 | APC-A*24:02/Human CA9 (EYRALQLHL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0427 | Hi-Affi™ Rabbit Anti-CA9 Recombinant Antibody (clone DS427AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H43 | Afuco™ Anti-CA9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H43) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY37 | AbPlus™ Anti-CA9 Magnetic Beads (12F10) | IP, Protein Purification | |
| VS-0724-YC1029 | AbPlus™ Anti-CA9 Magnetic Beads (VS-0724-YC1029) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY54 | Human Anti-CA9 (clone G37) scFv-Fc Chimera | FC, ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY290 | Anti-CA9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY911 | Anti-Mouse CA9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY912 | Anti-Human CA9 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC94 | Recombinant Anti-CA9 Vesicular Antibody, EV Displayed (VS-0425-YC94) | ELISA, FC, Neut, Cell-uptake |
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