What research applications have been demonstrated for the CAIX antibody?

Our CAIX antibody has been validated in Western blot, immunohistochemistry, ELISA, IP, and functional assays. Its ability to specifically bind CAIX, combined with high purity levels verified by RP-HPLC and SDS-PAGE, makes it a flexible and robust reagent for protein expression studies.

How do quality and storage guidelines support its use in research?

We ensure high quality through rigorous control and detailed storage instructions, including maintaining the antibody at -20°C in aliquots. With purity levels over 95% by RP-HPLC and SDS-PAGE, the CAIX antibody consistently performs well in multiple assays, providing reliable data for research investigations.

Anti-CAIX/CA9 Recombinant Antibody (Girentuximab)

CAT#: TAB-707

Recombinant chimeric antibody expressed in CHO binding to human CAIX. Girentuximab is a chimeric monoclonal antibody designed for the treatment of renal cell carcinoma.

Published Data Tested Data Gene Expression

IHC

Figure 4 Immunohistochemical analyses of vital tumor specimens from different groups.

Neoadjuvant treatment with sorafenib resulted in enhanced necrosis (hematoxylin and eosin) and decreased vessel density (CD31) but had no effect on CAIX expression.

Muselaers, C. H., Stillebroer, A. B., Desar, I. M., Boers-Sonderen, M. J., van Herpen, C. M., de Weijert, M. C.,... & Mulders, P. F. (2014). Tyrosine kinase inhibitor sorafenib decreases 111In-girentuximab uptake in patients with clear cell renal cell carcinoma. Journal of Nuclear Medicine, 55(2), 242-247.

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Figure 3 Anti-CAIX/CA9 Antibody (TAB-707) in Dot Blot

Dot Blot analysis of TAB-707 was performed by coating with Recombinant Human Carbonic Anhydrase IX Protein (his Tag).

TAB-707 incubation concentration: 1 ng/μL.
The secondary antibody: HRP-Anti-Human IgG (H+L)

ELISA

Figure 1 Anti-CAIX/CA9 Antibody (TAB-707) in ELISA

ELISA analysis of TAB-707 was performed by coating with Recombinant Human Carbonic Anhydrase IX Protein (his Tag). Then blocked with BSA and incubated with Anti-Human DR5 Antibody (TAB-707). The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.

Figure 2 Anti-CAIX/CA9 Antibody (TAB-707) in WB

Western blot analysis of TAB-707 was performed by loading Recombinant Human Carbonic Anhydrase IX Protein (his Tag) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-707 and HRP Goat Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.

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Normal Tissue Figure 1 Immunofluorescent staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg

Normal Tissue Figure 2 Stomach

Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Chimeric (Human/Mouse)

Type
IgG1 - kappa

Species Reactivity
Human

Applications
WB, FuncS, IF, Neut, ELISA, FC, IP, PK, IHC, Activ

Trade name
rencarex

CAS
916138-87-9

Generic Name
Girentuximab

UNII
539B57DFJF

MW
146.5 kDa

Related Disease
Renal cell carcinoma (RCC)

Product Property

Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

Application Notes
The CA9 antibody has been reported in applications of WB, FuncS, IF, Neut, ELISA, FC, IP, PK, IHC, Activ.

Target

Alternative Names
MN; CAIX

Gene ID
768

UniProt ID
Q16790

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Breast cancer biomarkers at key points during disease progression

Impressive CAIX Data

The CAIX antibody has delivered robust performance in Western blot and immunohistochemistry assays. I appreciated the thorough documentation regarding high purity and the chimeric design, which ensured reliable binding in my protein expression studies. The provided protocols were clear and very helpful for research applications.

Robust Research Tool

This antibody targeting CAIX has shown consistent results in ELISA, IP, and functional assays. The quality control details, especially the high purity levels above 95%, contributed to clear and reproducible experimental data. Its chimeric design supports reliable detection of CAIX, making it an excellent reagent for my research needs.

Q&As

What research applications have been demonstrated for the CAIX antibody?

A: Our CAIX antibody has been validated in Western blot, immunohistochemistry, ELISA, IP, and functional assays. Its ability to specifically bind CAIX, combined with high purity levels verified by RP-HPLC and SDS-PAGE, makes it a flexible and robust reagent for protein expression studies.
How do quality and storage guidelines support its use in research?

A: We ensure high quality through rigorous control and detailed storage instructions, including maintaining the antibody at -20°C in aliquots. With purity levels over 95% by RP-HPLC and SDS-PAGE, the CAIX antibody consistently performs well in multiple assays, providing reliable data for research investigations.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-707, RRID: AB_3111986)

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Biosimilar Overview

Please refer to Girentuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Girentuximab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-707.pdf

MSDS

MSDS - TAB-707.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Girentuximab"

Afuco™ Anti-CA9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H43)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Chimeric antibody to Human CA9.

DrugMonitor™ Anti-Girentuximab Antibody (VS-1224-YC521)
Girentuximab is a chimeric (mouse/human) monoclonal antibody targeting carbonic anhydrase IX, expressed in 95% of clear cell renal cell carcinomas (RCC). The DrugMonitor™ Anti-Girentuximab Antibody (VS-1224-YC521) is an anti-drug antibody (ADA) against Girentuximab. This drug-based antibody is raised in mice immunized with the Girentuximab. The anti-Girentuximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Girentuximab in samples.

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HPAB-0104-LSX-F(E)	Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0104-LSX-F(E))	ELISA	Human Fab

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HPAB-0105-LSX-F(E)	Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0105-LSX-F(E))	ELISA	Human Fab

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