Human Anti-CA9 (clone G37) scFv-Fc Chimera (CAT#: VS-0325-FY54)
An anti-CA9 scFv-Fc antibody is a recombinant antibody that combines the antigen-binding capabilities of a single-chain variable fragment (scFv) with the effector functions of an immunoglobulin's fragment crystallizable (Fc) region. CA9 stands for carbonic anhydrase IX. Anti-CA9 scFv-Fc antibodies have been used in research to treat renal cell carcinoma (RCC) cells. They have also been used in the development of bispecific antibodies that target both CA9 and CD55.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Immunofluorescent staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
Figure 2 Stomach
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CA9
- Species Reactivity
- Human
- Clone
- G37
- Applications
- Flow Cytometry, ELISA, Inhibition
- Related Disease
- Renal cell carcinoma (RCC)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 5 μg/mL
Target
- Alternative Names
- MN; CAIX
- Gene ID
- 768
- UniProt ID
- Q16790
- Long Name
- carbonic anhydrase 9
- Sequence Similarities
- Belongs to the alpha-carbonic anhydrase family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Asn-346 bears high-mannose type glycan structures.
Glycosylation at Thr115 and Asn346
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 4 O-linked glycans (2 sites)
- Protein Refseq
- XP_047279805.1; XP_047279806.1; XP_054219735.1; XP_054219736.1; NP_001207.2
- Function
- Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e.
bicarbonate and hydrogen ions).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1276z | Mouse Anti-CA9 Recombinant Antibody (clone 21C7) | ELISA, FC, IHC, WB | Mouse IgG1, κ |
| HPAB-1174WJ | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.5.2) | ADCC | Mouse IgG1 |
| HPAB-1175WJ | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.6.1) | ADCC | Mouse IgG1 |
| VS3-WK1020 | Mouse Anti-CA9 Recombinant Antibody (VS3-WK1020) | WB, IHC, IP | Mouse IgG |
| VS3-WK1021 | Rabbit Anti-CA9 Recombinant Antibody (VS3-WK1021) | WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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