Human Anti-Aβ42 Recombinant Antibody (clone HT7) (CAT#: HPAB-A1231-YJ)

Figure 1 Dot Blot analysis of Aβ42 monomers, oligomers, protofibrils, and fibrils (10 μM each, 10 μL each) probed with B4 and scFv HT7.

Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.

Figure 2 Western Blot analysis of various Aβ42 species, ranging from Aβ42 monomers to fibrils, probed with scFv HT7, and the mixture of the four Aβ42 species was probed with B4 antibody (positive control).

Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.

Figure 3 Effects of scFv HT7 on Aβ42-induced cytotoxicity as estimated by MTT cell viability.

Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.

Figure 4 Neutralization and inhibition of Aβ42-induced cytotoxicity by scFv HT7 were compared by MTT assay.

Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.

Figure 5 SH-SY5Y cell profiles in the presence of Aβ42 oligomers or Aβ42 oligomers plus scFv HT7.

Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.

Figure 6 Robust somatodendritic tau accumulation was detected in the brains of 3xTg-AD mice at 6, 12, and 18 months of age using the human specific tau antibody HT7.

Oddo, S., Caccamo, A., Tseng, B., Cheng, D., Vasilevko, V., Cribbs, D. H., & LaFerla, F. M. (2008). Blocking Aβ42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Aβ and tau pathology. Journal of Neuroscience, 28(47), 12163-12175.