Afuco™ Anti-CCR2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-444CQ)
CAT#: AFC-TAB-444CQ
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CCR2. It is a humanized monoclonal antibody that can be potentially used in the treatment of Atherosclerosis, Diabetic nephropathies, Malignant melanoma. It binds to CCR2 and prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63255/1926_C6_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cervix, uterine
Immunohistochemical staining of human cervix, uterine shows strong cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/ihc_selected.jpg
Normal Tissue
Figure 3 Cervix
Squamous epithelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_B_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000121807-CCR2
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human CCR2
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Generic Name
- Plozalizumab
- Related Disease
- Atherosclerosis, Diabetic nephropathies, Malignant melanoma
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Plozalizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Plozalizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Plozalizumab"
Anti-Human CCR2 Recombinant Antibody (Plozalizumab)Recombinant monoclonal antibody to CCR2. Plozalizumab is a humanized monoclonal antibody that can be potentially used in the treatment of Atherosclerosis, Diabetic nephropathies, Malignant melanoma. It binds to CCR2 and prevents binding of the endothelium-derived CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2.
DrugMonitor™ Anti-Plozalizumab Antibody (VS-1224-YC931)Plozalizumab has been researched for treating atherosclerosis as a humanized monoclonal antibody specifically targeting CCR2. The DrugMonitor™ Anti-Plozalizumab Antibody (VS-1224-YC931) is an anti-drug antibody (ADA) against Plozalizumab. This drug-based antibody is raised in mice immunized with the Plozalizumab. The anti-Plozalizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Plozalizumab in samples.
See other products for "CCR2"
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