Human Anti-CD27 Recombinant Antibody Hexamer (VS-0924-YC109), CDC Enhanced (CAT#: VS-0924-YC109)

• Host Species
• Human

• Derivation
• Humanized

• Type
• Antibody hexamer

• Specificity
• Human CD27

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• ELISA, CDC, SPR

• Conjugate
• None

• Related Disease
• Cancer

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• CD27; CD27 molecule; T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7

• Gene ID
• 939

• UniProt ID
• P26842

• Long Name
• CD27 Molecule

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein

• Post Translation Modifications
• Phosphorylated. ( P26842-CD27_HUMAN )
  N-glycosylated. ( P26842-CD27_HUMAN )
  O-glycosylated with core 1 or possibly core 8 glycans. ( P26842-CD27_HUMAN )
  Glycosylation at Asn95 and Ser127 ( NX_P26842 [NX_P26842-1] )

• Function
• Receptor specifically expressed at the surface of T cells which binds and is activated by its ligand CD70/CD27L expressed by B cells (PubMed:28011863).
  The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells

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