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CD27

Anti-CD27 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
CD27
Protein class

Cancer-related genes, CD markers, Disease related genes, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Plasma cells, B-cells, T-cells, Melanocytes)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Group enriched (Daudi, U-698)

Interaction

Homodimer. Interacts with SIVA1 and TRAF2.

Molecular function

Receptor

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