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CD27

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For Research Use Only. Not For Clinical Use.


Enables transmembrane signaling receptor activity. Involved in CD27 signaling pathway; negative regulation of apoptotic process; and positive regulation of JNK cascade. Acts upstream of or within negative regulation of T cell apoptotic process. Located in external side of plasma membrane. Is active in plasma membrane. Is expressed in several structures, including femur; hemolymphoid system; intestine; pituitary gland; and reproductive system. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2. Orthologous to human CD27 (CD27 molecule).
CD27
Protein class

Cancer-related genes, CD markers, Disease related genes, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Plasma cells, B-cells, T-cells, Melanocytes)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Group enriched (Daudi, U-698)

Interaction

Homodimer. Interacts with SIVA1 and TRAF2.

Molecular function

Receptor

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