This product is a mouse antibody directed against human IAP. The antibody can be used as prevention and/or treatment for a variety of diseases, such as cancer, inflammation, hormonal disorders, and blood disorders. This antibody specifically binds to L1210 cells expressing human IAP.
Figure 1 A graph shows the antibodies combining humanized H chain versions 1.4 and 1.5 with a chimeric L chain have binding activities comparable to those of the chimeric antibody and version 1.3.
Figure 2 A graph shows the humanized MABL-1 antibody combining humanized H chain version 2.1 with humanized L chain version 2.1 has a binding inhibitory activity by MABL-1 comparable to that of the chimeric antibody.
Figure 3 A graph shows the humanized MABL-1 antibody and the humanized MABL-2 antibody induce cell death in L1210 cells containing the human IAP gene, respectively.
Figure 4 Shows the results of reducing and non-reducing SDS-PAGE analyses of purified humanized MABL-1 antibody HL5 and sc(Fv)2.
HL5 showed a single band at a position of the molecular weight of a monomer (about 30 kDa) under both conditions, and sc(Fv)2 showed a single band at a position of the molecular weight of a monomer (about 55 kDa) under both conditions.
Figure 5 A graph shows the humanized MABL-2 antibody HL5 and sc(Fv)2 and the humanized MABL-1 antibody HL5 and sc(Fv)2 induce cell death in MOLT4 cells.
Figure 6 A diagram shows the humanized MABL-1 antibody sc(Fv)2 has a life-extending effect in a mouse model of human leukemia.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1122z | Mouse Anti-CD47 Recombinant Antibody (clone 23B12) | WB, FC, IHC, IP, FuncS | Mouse IgG2b |
HPAB-0093-CN | Human Anti-CD47 Recombinant Antibody (HPAB-0093-CN) | ELISA, FC | Chimeric (mouse/human) IgG1, κ |
HPAB-0008-FY | Human Anti-CD47 Recombinant Antibody (HPAB-0008-FY) | ELISA, PD, Activ, PK, Stim | Humanized IgG |
HPAB-1082LY | Human Anti-CD47 Recombinant Antibody (HPAB-1082LY) | ELISA | Human IgG |
HPAB-1083LY | Human Anti-CD47 Recombinant Antibody (HPAB-1083LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-278LC | Human Anti-CD47 Recombinant Antibody (TAB-278LC) | Block, FuncS | Human IgG, κ |
TAB-279LC | Human Anti-CD47 Recombinant Antibody (TAB-279LC) | Block, FuncS | Human IgG, κ |
TAB-278LC-S(P) | Human Anti-CD47 Recombinant Antibody; scFv Fragment (TAB-278LC-S(P)) | ELISA | Human scFv |
TAB-278LC-F(E) | Human Anti-CD47 Recombinant Antibody; Fab Fragment (TAB-278LC-F(E)) | ELISA | Human Fab |
TAB-279LC-F(E) | Human Anti-CD47 Recombinant Antibody; Fab Fragment (TAB-279LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-280LC | Human Anti-CD47 Recombinant Antibody (TAB-280LC) | ELISA | Humanized antibody |
TAB-281LC | Human Anti-CD47 Recombinant Antibody (TAB-281LC) | ELISA | Humanized antibody |
TAB-282LC | Human Anti-CD47 Recombinant Antibody (TAB-282LC) | ELISA | Humanized antibody |
TAB-283LC | Human Anti-CD47 Recombinant Antibody (TAB-283LC) | ELISA | Humanized antibody |
TAB-284LC | Human Anti-CD47 Recombinant Antibody (TAB-284LC) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-387CQ | Mouse Anti-CD47 Recombinant Antibody (clone CBL377) | Block, FC, CyTOF | Mouse IgG1 |
NEUT-388CQ | Mouse Anti-CD47 Recombinant Antibody (clone MIAP410) | Block, IF | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-389CQ | Rat Anti-CD47 Recombinant Antibody (clone miap301) | FC, FuncS, Neut, WB | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0565 | Hi-Affi™ Rabbit Anti-CD47 Recombinant Antibody (clone DS565AB) | WB, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0008-FY-F(E) | Human Anti-CD47 Recombinant Antibody; Fab Fragment (HPAB-0008-FY-F(E)) | ELISA | Humanized Fab |
HPAB-0834-CN-F(E) | Mouse Anti-CD47 Recombinant Antibody; Fab Fragment (HPAB-0834-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
HPAB-0835-CN-F(E) | Human Anti-CD47 Recombinant Antibody; Fab Fragment (HPAB-0835-CN-F(E)) | ELISA, FC, Neut | Chimeric (mouse/human) Fab |
HPAB-0836-CN-F(E) | Mouse Anti-CD47 Recombinant Antibody; Fab Fragment (HPAB-0836-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
HPAB-0837-CN-F(E) | Human Anti-CD47 Recombinant Antibody; Fab Fragment (HPAB-0837-CN-F(E)) | ELISA, FC, Neut | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0037-YC-S(P) | Human Anti-CD47 Recombinant Antibody (clone ZFlY1-93Y94P); scFv Fragment | ELISA, FC, Block | Humanized scFv |
HPAB-N0039-YC-S(P) | Human Anti-CD47 Recombinant Antibody; scFv Fragment (HPAB-N0039-YC-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-N0040-YC-S(P) | Human Anti-CD47 Recombinant Antibody; scFv Fragment (HPAB-N0040-YC-S(P)) | ELISA | Human scFv |
HPAB-N0041-YC-S(P) | Human Anti-CD47 Recombinant Antibody; scFv Fragment (HPAB-N0041-YC-S(P)) | ELISA, Block | Human scFv |
HPAB-N0042-YC-S(P) | Human Anti-CD47 Recombinant Antibody; scFv Fragment (HPAB-N0042-YC-S(P)) | ELISA, Block | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP496-YC | Recombinant Alpaca Anti-CD47 Single Domain Antibody (A4) | FC, BL, FuncS | Alpaca VHH |
HPAB-AP497-YC | Recombinant Alpaca Anti-CD47 Single Domain Antibody (F2) | FC | Alpaca VHH |
NBD-0016-YJ-VHH | Camelid Anti-CD47 Recombinant Single Domain Antibody (Nb02) | ELISA, SPR | Camelid VHH |
NBD-0017-YJ-VHH | Camelid Anti-CD47 Recombinant Single Domain Antibody (M2) | ELISA, SPR | Camelid VHH |
NBD-0018-YJ-VHH | Camelid Anti-CD47 Recombinant Single Domain Antibody (M7) | ELISA, SPR | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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