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    Recombinant Alpaca Anti-CD47 Single Domain Antibody (HPAB-AP496-YC) (CAT#: HPAB-AP496-YC)

    Provided are sdAb clones that antagonize the mouse CD47–SIRPα interaction. A4 was specific for mouse CD47, with minimal cross-reactivity toward human CD47 at concentrations up to 1 μM. Also, it was reported that A4, H5, and H9 blocked SIRPα tetramer binding to surface-disposed CD47.

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    • Endotoxin:

    • Purity:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16055/204_F3_1_selected.jpg
    Figure 2 IHC staining of human urinary bladder
    Figure 2 IHC staining of human urinary bladder
    (Immunohistochemical staining of human urinary bladder shows strong cytoplasmic and membranous positivity in urothelial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44659/ihc_selected.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16055/205_F3_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Neuropil
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44659/124851_B_8_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44659/124851_A_8_3.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Elongated or late spermatids
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44659/124851_A_4_6.jpg
    Figure 7 Prostate
    Figure 7 Prostate
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44659/124851_A_2_5.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196776-CD47
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196776-CD47

    Specifications

    • Immunogen
    • The extracellular Ig-like V-type domain (ECD) of mouse CD47, which is the sole extracellular domain that mediates interaction with SIRPα.
    • Host Species
    • Alpaca
    • Type
    • Alpaca VHH
    • Specificity
    • Mouse
    • Species Reactivity
    • Mouse
    • Clone
    • HPAB-AP496-YC
    • Applications
    • Flow Cytometry, Block, Function Assay

    Product Property

    • Storage
    • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles

    Target

    • Alternative Names
    • IAP; OA3; MER6

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "CD47"

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    Please select product type
    Human Antibody Products Humanized Antibody Products Blocking Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products Single Domain Antibody Products IgG Antibody Products ScFv Antibody Products IgM Antibody Products Non-Human Primate (NHP) Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    TAB-278LC Human Anti-CD47 Recombinant Antibody (TAB-278LC) Block, FuncS Human IgG, κ
    TAB-278LC-S(P) Human Anti-CD47 Recombinant Antibody; scFv Fragment (TAB-278LC-S(P)) ELISA Human scFv
    TAB-279LC-S(P) Human Anti-CD47 Recombinant Antibody; scFv Fragment (TAB-279LC-S(P)) ELISA Human scFv
    TAB-278LC-F(E) Human Anti-CD47 Recombinant Antibody; Fab Fragment (TAB-278LC-F(E)) ELISA Human Fab
    TAB-279LC-F(E) Human Anti-CD47 Recombinant Antibody; Fab Fragment (TAB-279LC-F(E)) ELISA Human Fab

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