Human Anti-CD8A Recombinant Antibody (clone ZED8)
CAT#: VS-0724-XY73
ZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8A. The antibody binds to human CD8A with reduced affinity but it has no measurable affinity for rat or mouse CD8A. It may monitor tumor CD8A status in patients undergoing cancer immunotherapy.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1373_A3_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1492_D3_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1377_A3_1_blue_red_green.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12/97_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000153563-CD8A
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- CD8A
- Species Reactivity
- Human
- Clone
- ZED8
- Applications
- ELISA, SPR, FC
- Related Disease
- Immunodeficiency 116; Lymphoid Interstitial Pneumonia
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- SPR: The KD value of ZED8 agaisnt human CD8A is 66 nM.
Target
- Alternative Names
- CD8; p32; Leu2; IMD116; CD8alpha
- Gene ID
- 925
- UniProt ID
- P01732
- Cellular Localization
- Cell membrane
- Protein Refseq
- NP_001139345.1; NP_001369627.1; NP_001759.3
- Function
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.
The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.
Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
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- Product Name
Secondary Antibody
- CAT
- Product Name
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