Human Anti-CDH17 Recombinant Antibody (clone AV17.3) (CAT#: VS-0524-YC24)
The antibody is capable of binding human cadherin-17 domain 1-2 produced by CHO-S cells. The Biacore analysis demonstrates that scFv(AV17.3) had an affinity (KD) for the human Cadherin-17 of 843 nM and a KD for the murine Cadherin-17 of 640 nM. Immunofluorescence analysis was carried out on human biopsy samples of Ulcerative Colitis.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
Figure 2 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
Figure 3 Small intestine
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
Figure 4 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, OE19, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
Specifications
- Immunogen
- Domain 1-2 of cadherin-17 (located in the extra-cellular part of the protein) was produced in CHO-S cells.
- Host Species
- Human
- Derivation
- Antibody phage display
- Type
- Human IgG
- Specificity
- Human and mouse Cadherin-17
- Species Reactivity
- Human, Mouse
- Clone
- AV17.3
- Applications
- ELISA, IF
- Related Disease
- Cone-Rod Dystrophy 15 and Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome.
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Cadherin 17; Intestinal Peptide-Associated Transporter HPT-1; Cadherin 17, LI Cadherin (Liver-Intestine); Liver-Intestine Cadherin; Human Intestinal Peptide-Associated Transporter HPT-1; Human Peptide Transporter 1; HPT-1 Cadherin; Cadherin-16;
- Gene ID
- 1015
- UniProt ID
- Q12864
- Long Name
- cadherin-17
- Post Translation Modifications
- Glycosylation at Asn149, Asn184, Asn250, Asn419, Asn456, Asn546, Asn587, and Asn722
- Protein Refseq
- NP_001138135.1; NP_001400880.1; NP_001400881.1; NP_001400882.1; NP_001400883.1
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2803z | Mouse Anti-CDH17 Recombinant Antibody (clone 23F8) | WB, ELISA, IHC | Mouse IgG1 |
| HPAB-2061LY | Human Anti-CDH17 Recombinant Antibody (clone D2101) | ELISA | Human IgG |
| HPAB-2062LY | Human Anti-CDH17 Recombinant Antibody (clone D2111) | ELISA | Human IgG |
| VS3-QX207 | Mouse Anti-CDH17 Recombinant Antibody (clone D10-E1) | WB, IHC | Mouse IgG1 |
| VS-0723-WK84 | Human Anti-CDH17 Recombinant Antibody (VS-0723-WK84) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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