Human Anti-CDH17 Recombinant Antibody (clone D2107)
CAT#: HPAB-2067LY
This product is antibody recognizes CDH17. The antibody D2107 can be used in some immunoassay techniques such as: ELISA.
Published Data
Gene Expression
Figure 1 Competition assay of the hybridoma culture supernatant.
All of the data shown are the means-standard deviations of triplicate assays.
Kusano-Arai, O., Iwanari, H., Kudo, S., Kikuchi, C., Yui, A., Akiba, H.,... & Hamakubo, T. (2018). Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17. Monoclonal antibodies in immunodiagnosis and immunotherapy, 37(1), 1-11.
FC
Figure 2 Specific binding to the cell surface CDH17 was demonstrated by flow cytometry.
The filled histograms indicate anti-CDH17 mAbs, and the open histograms indicate control IgG binding to AGS cells (upper panels) and MKN74 cells (lower panels). The numbers at the top designate the clone number of the anti-CDH17 mAbs. CDH17, Cadherin-17; mAb, monoclonal antibody.
Kusano-Arai, O., Iwanari, H., Kudo, S., Kikuchi, C., Yui, A., Akiba, H.,... & Hamakubo, T. (2018). Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17. Monoclonal antibodies in immunodiagnosis and immunotherapy, 37(1), 1-11.
ELISA
Figure 3 Dose-dependent binding of the anti-CDH17 mAbs.
All of the data shown are the means-standard deviations of triplicate assay.
Kusano-Arai, O., Iwanari, H., Kudo, S., Kikuchi, C., Yui, A., Akiba, H.,... & Hamakubo, T. (2018). Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17. Monoclonal antibodies in immunodiagnosis and immunotherapy, 37(1), 1-11.
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Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
Normal Tissue
Figure 2 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
Normal Tissue
Figure 3 Small intestine
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, OE19, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human CDH17
- Species Reactivity
- Human
- Clone
- D2107
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-Linked Immunosorbent Assay and Flow Cytometry.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- CAT
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| CAT | Product Name | Application | Type |
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| HPAB-2061LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2101); scFv Fragment | ELISA | Human scFv |
| HPAB-2062LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2111); scFv Fragment | ELISA | Human scFv |
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