SmartAb™ Recombinant Anti-CDH3 pH-dependent Antibody (Clone 194-b09)
CAT#: VS-0825-YC73
The anti-CDH3 pH-dependent antibody (clone 194-b09) is a pH-responsive antibody engineered to target both human and mouse CDH3. This pH-switched monoclonal antibody (mAb) was developed by incorporating histidine residues into its variable regions, which results in pH-biased binding to CDH3. By leveraging the natural pH variations in different tissues and cellular compartments, this pH-responsive antibody facilitates precise targeting of CDH3 on cells and tissues. CDH3, also known as P-cadherin, is a cell adhesion protein expressed on various epithelial cells. It plays a role in cell-cell adhesion and tissue architecture, and its dysregulation has been linked to cancer progression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/1032_G9_1_selected.jpg
Normal Tissue
Figure 2 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_B_8_1_val_selected.jpg
Normal Tissue
Figure 3 Oral mucosa
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Moderate Quantity:>75% Distal tubules Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000062038-CDH3
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Specifications
- Immunogen
- Recombinant human P-cadherin protein.
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG1
- Specificity
- Human and Mouse CDH3
- Species Reactivity
- Human, Mouse
- Clone
- 194-b09
- Applications
- ELISA, FC
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| HPAB-0142CQ | Human Anti-CDH3 Recombinant Antibody (clone 194-b09) | ELISA, FC | Human IgG1 |
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| CAT | Product Name | Application | Type |
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| HPAB-0142CQ-F(E) | Human Anti-CDH3 Recombinant Antibody (clone 194-b09); Fab Fragment | ELISA, FC | Human Fab |
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| HPAB-0142CQ-S(P) | Human Anti-CDH3 Recombinant Antibody (clone 194-b09); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0143CQ-S(P) | Human Anti-CDH3 Recombinant Antibody (clone 194-g09); scFv Fragment | ELISA, FC | Human scFv |
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