Recombinant Anti-CDK4 Soluble TCR (UNC-CDK4-1) (C-Cys) (CAT#: VS-0622-YF3593)
TCR (UNC-CDK4-1) recognizes CDK4 peptide (ALTPVVVTL) in the context of HLA-A*02:01. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
Figure 2 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
Figure 3 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (HBEC3-KT, LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
Specifications
- Target
- CDK4
- Species Reactivity
- Human
- Epitope
- ALTPVVVTL
- MHC
- HLA-A*02:01
- Clone
- UNC-CDK4-1
- Type
- Soluble TCR (C-Cys)
- Related Disease
- Acute myeloid leukemia (AML)
- TCR Expression Strategy
- C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.
Target
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