Recombinant Anti-CDK4 Soluble TCR (UNC-CDK4-1) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF885)
TCR (UNC-CDK4-1) recognizes CDK4 peptide (ALTPVVVTL) in the context of HLA-A*02:01. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant soluble TCR (UNC-CDK4-1). Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
Figure 2 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
Figure 3 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (HBEC3-KT, LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
Specifications
- Target
- CDK4
- Species Reactivity
- Human
- Epitope
- ALTPVVVTL
- MHC
- HLA-A*02:01
- Clone
- UNC-CDK4-1
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- Related Disease
- Acute myeloid leukemia (AML)
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
Related Resources
Bladder Cancer
AGE-RAGE Signaling Pathway in Diabetic Complications
p53 Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone UNC-CDK4-1"
See other products for "CDK4"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibodies
Chicken IgY Antibodies
Rabbit Monoclonal Antibodies
Antibody Magnetic Beads
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0519CT | Recombinant Mouse anti-Human CDK4 Monoclonal antibody (EML005) | ICC, IF, WB | |
| ZG-0404F | Mouse Anti-Cdk4 Recombinant Antibody (ZG-0404F) | WB | Mouse IgG |
| ZG-0405F | Mouse Anti-CDK4 Recombinant Antibody (ZG-0405F) | WB | Mouse IgG |
| VS3-FY346 | Recombinant Rabbit Anti-CDK4 Antibody (clone R04-4I5) | WB, IHC-F, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS3-FY347 | Recombinant Rabbit Anti-CDK4 Antibody (clone R04-8I5) | WB, ICC, IF, IP | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0622-YF885. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-2-1.png)
Application: ELISA
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: ELISA, FC, WB, Inhib, IHC
Application: ELISA, Neut, FuncS
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
