Rabbit Anti-CXCL12 Recombinant Antibody (VS3-CJ980)
CAT#: VS3-CJ980
This product is a rabbit antibody that recognizes human CXCL12.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_6_6.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107562-CXCL12
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CXCL12
- Species Reactivity
- Human
- Applications
- WB, ICC, IF
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence.
Target
- Alternative Names
- IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
- Gene ID
- 6387
- UniProt ID
- P48061
- Sequence Similarities
- Belongs to the intercrine alpha (chemokine CxC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
- Protein Refseq
- NP_000600.1; NP_001029058.1; NP_001171605.1
- Function
- Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984).
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CXCL12"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256 | Recombinant Anti-human CXCL12 Antibody | ELISA, WB, FC, FuncS | IgG |
| HPAB-0050LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0050LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0051LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0051LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0052LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0052LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0053LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0053LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-F(E) | Recombinant Anti-human CXCL12 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| MHH-256-F(E) | Recombinant Human Anti-human CXCL12 Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
| PFBL-057 | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (PFBL-057) | FC, ELISA, FuncS | Human Fab |
| HPAB-632-FY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-632-FY-F(E)) | Inhib | Chimeric (Mouse/Human) Fab |
| HPAB-633-FY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-633-FY-F(E)) | Block | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-S(P) | Recombinant Anti-human CXCL12 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-256-S(P) | Recombinant Human Anti-human CXCL12 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| PSBL-057 | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (PSBL-057) | FC, ELISA, FuncS | Human scFv |
| HPAB-0050LY-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0050LY-S(P)) | Block, ELISA, WB, RIA, FC | Human scFv |
| HPAB-0051LY-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0051LY-S(P)) | Block, ELISA, WB, RIA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-040 | Recombinant Anti-Human CXCL12 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| HPAB-0348-YC-VHH | Llama Anti-CXCL12 Recombinant Antibody; VHH Fragment (HPAB-0348-YC-VHH) | FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-415CT | Anti-Human CXCL12 Recombinant Antibody (30D8) | Inhib, WB, FC, Funcs, ELISA, Neut | |
| TAB-415CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (30D8) | WB, ELISA, Neut, FC | |
| TAB-415CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (30D8) | WB, ELISA, Neut, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-416CT | Anti-Human CXCL12 Recombinant Antibody (hu30D8) | Funcs, FC, PK, ELISA, Neut, WB | Humanized antibody |
| TAB-416CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
| TAB-416CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-417CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-417CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-417CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-417CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-418CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-418CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-419CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-419CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-420CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-420CT-F(E)) | BL, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-612CQ | Mouse Anti-CXCL12 Recombinant Antibody (clone CBL825) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0884 | Hi-Affi™ Rabbit Anti-CXCL12 Recombinant Antibody (clone DS884AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY17 | Hamster Anti-CXCL12 scFv-Fc Chimera (VS-0425-FY17) | ELISA, Block | Hamster IgG, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1813 | Anti-CXCL12 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1814 | Anti-Rat CXCL12 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC82 | Recombinant Anti-CXCL12 Eliminating Antibody, pH-Sensitive (hu30D8 var.) | Antigen-Sweeping In Vivo. | Human IgG |
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