Anti-CXCR4 Antibody Prodrug, Protease Activated (hz515H7VH1D76NVL2)

Name: Anti-CXCR4 Antibody Prodrug, Protease Activated (hz515H7VH1D76NVL2)
SKU: VS-1025-YC44
Rating: 5 (1 reviews)

CAT#: VS-1025-YC44

The Anti-CXCR4 Antibody Prodrug, Protease Activated (hz515H7VH1D76NVL2) is an antibody prodrug comprised of a recombinant human antibody targeting human CXCR4, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CXCR4 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CXCR4 effectively. CXCR4 is a chemokine receptor that plays a critical role in cell migration and is a major mediator of metastasis in many solid tumors, including breast and pancreatic cancer. Its binding to its ligand, CXCL12, promotes cell survival and directs the movement of tumor cells to specific organs that express high levels of CXCL12 (e.g., bone marrow and liver).

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human CXCR4

Target
CXCR4

Species Reactivity
Human

Isotype
IgG1, kappa

Clone
hz515H7VH1D76NVL2

Epitope
CXCR4-ECD

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative Names
D2S201E; HSY3RR; NPYY3R; CXCR-4; CD184; NPY3R; WHIMS; NPYR; LAP3; WHIM

Gene ID
7852

UniProt ID
P61073

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Datasheet

Datasheet - VS-1025-YC44.pdf

MSDS

MSDS - VS-1025-YC44.pdf

COA

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