Human Anti-CXCR4 (clone 6C7) scFv-Fc Chimera (CAT#: VS-0325-FY55)
Anti-CXCR4 scFv-Fc is a recombinant protein that consists of a single-chain variable fragment (scFv) fused to the Fc region of an immunoglobulin (IgG). This format allows the protein to have high specificity and affinity for the CXCR4 receptor, which is known to play a crucial role in various physiological and pathological processes, including hematopoiesis, immune response, and cancer metastasis.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
Specifications
- Immunogen
- Transfection of human CXCR4 gene into Chinese hamster ovary (CHO) cells.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CXCR4
- Species Reactivity
- Human
- Clone
- 6C7
- Applications
- Blocking, ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: 6C7, a fully human monoclonal antibody against CXCR4, effectively inhibits AKT phosphorylation induced by SDF-1 in cynomolgus HSC-F cells at a concentration of 10 µg/mL.
Flow Cytometry: 0.5 μg/mL
Target
- Alternative Names
- C-X-C Motif Chemokine Receptor 4; Leukocyte-Derived Seven Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; Chemokine (C-X-C Motif) Receptor 4; LPS-Associated Protein 3; SDF-1 Receptor; CD184 Antigen; Fusin; LAP-3; LESTR; NPYRL; FB22; HM89; LCR1; Seven-Transmembrane-Segment Receptor, Spleen; Chemokine (C-X-C Motif), Receptor 4 (Fusin)
- Gene ID
- 7852
- UniProt ID
- P61073
- Long Name
- C-X-C Motif Chemokine Receptor 4
- Cellular Localization
- Cell membrane; Cell junction
- Post Translation Modifications
- Glycosylation at Asn11, Ser18, and Asn176
Ubiquitination at Lys310, Lys327, and Lys331
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_047301758.1; NP_001008540.1
- Function
- Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g.during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0011CL-S(P) | Mouse Anti-CXCR4 Recombinant Antibody scFv Fragment (TAB-0011CL-S(P)) | FC, IHC, Block, Inhib, FuncS | |
| TAB-143MZ-S(P) | Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-143MZ-S(P)) | cAMP Assay | Mouse scFv |
| TAB-144MZ-S(P) | Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-144MZ-S(P)) | cAMP Assay | Mouse scFv |
| TAB-145MZ-S(P) | Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-145MZ-S(P)) | cAMP Assay | Mouse scFv |
| TAB-149MZ-S(P) | Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-149MZ-S(P)) | FC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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