CXCR4
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- Derivation: human
- Species Reactivity: Human
- Type: IgG4 - kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, ICC, IHC, FuncS
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- Anti-Human CXCR4 Recombinant Antibody (CF172) (TAB-150MZ)
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- Type: Human antibody
- Application: FC
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- Anti-Human CXCR4 Recombinant Antibody (5C9) (TAB-151MZ)
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- Type: Human antibody
- Application: FuncS
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- Anti-Human CXCR4 Recombinant Antibody (5E1) (TAB-152MZ)
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- Type: Human antibody
- Application: FuncS
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- Anti-Human CXCR4 Recombinant Antibody (7C8) (TAB-153MZ)
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- Type: Human antibody
- Application: FuncS, Inhib
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- Anti-Human CXCR4 Recombinant Antibody (6C7) (TAB-154MZ)
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- Species Reactivity: Cynomolgus
- Type: Human antibody
- Application: Block, FuncS, Inhib
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- Anti-Human CXCR4 Recombinant Antibody scFv Fragment (CF172) (TAB-150MZ-S(P))
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- Type: Human antibody
- Application: FC
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- Anti-Human CXCR4 Recombinant Antibody scFv Fragment (5C9) (TAB-151MZ-S(P))
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- Type: Human antibody
- Application: WB, ELISA
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- Anti-Human CXCR4 Recombinant Antibody scFv Fragment (5E1) (TAB-152MZ-S(P))
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- Type: Human antibody
- Application: WB, ELISA
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-142MZ-F(E)) (TAB-142MZ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Anti-Human CXCR4 Recombinant Antibody Fab Fragment (5C9) (TAB-151MZ-F(E))
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- Type: Human antibody
- Application: WB, ELISA
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- Anti-Human CXCR4 Recombinant Antibody Fab Fragment (5E1) (TAB-152MZ-F(E))
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- Type: Human antibody
- Application: WB, ELISA
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- Anti-Human CXCR4 Recombinant Antibody Fab Fragment (7C8) (TAB-153MZ-F(E))
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- Type: Human antibody
- Application: WB, ELISA
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- Anti-Human CXCR4 Recombinant Antibody Fab Fragment (6C7) (TAB-154MZ-F(E))
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- Species Reactivity: Cynomolgus
- Type: Human antibody
- Application: WB, ELISA
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- Mouse Anti-CXCR4 Recombinant Antibody (clone CBL046) (NEUT-687CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: FC, IHC, Neut
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- Mouse Anti-CXCR4 Recombinant Antibody (clone CBL470) (NEUT-688CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC, CyTOF®, Neut
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- Mouse Anti-CXCR4 Recombinant Antibody (clone CBL783) (NEUT-689CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Neut
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- Mouse Anti-CXCR4 Recombinant Antibody (clone CBL784) (NEUT-690CQ)
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- Species Reactivity: Human, Feline
- Type: Mouse IgG2b
- Application: FC, IHC, CyTOF®, Neut
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- Rat Anti-Cxcr4 Recombinant Antibody (clone 30L4) (NEUT-692CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b
- Application: Neut, FC, IHC, IHC-P, CyTOF®
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- Rat Anti-Cxcr4 Recombinant Antibody (clone CBL731) (NEUT-693CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b
- Application: FC, IHC, CyTOF®, ICC, Neut
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- Rat Anti-Cxcr4 Recombinant Antibody (clone CBL868) (NEUT-694CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: FC, IHC, Neut
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- Anti-Human CXCR4 Recombinant Antibody Fab Fragment (CF172) (TAB-150MZ-F(E))
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- Type: Human antibody
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody (clone 12G5R) (NEUT-685CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0659-CN) (HPAB-0659-CN)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0660-CN) (HPAB-0660-CN)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0661-CN) (HPAB-0661-CN)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, Neut
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- Derivation: human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: IP, IF, FuncS, FC, Neut, ELISA
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- Anti-Human CXCR4 Recombinant Antibody scFv Fragment (7C8) (TAB-153MZ-S(P))
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- Type: Human antibody
- Application: WB, ELISA
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- Anti-Human CXCR4 Recombinant Antibody scFv Fragment (6C7) (TAB-154MZ-S(P))
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- Species Reactivity: Cynomolgus
- Type: Human antibody
- Application: WB, ELISA
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-146MZ-F(E)) (TAB-146MZ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: cAMP Assay
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-147MZ-F(E)) (TAB-147MZ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: cAMP Assay
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-148MZ-F(E)) (TAB-148MZ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: cAMP Assay
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-155MZ-F(E)) (TAB-155MZ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody (clone 12G5) (NEUT-684CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, CyTOF®, Neut
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0374LY) (HPAB-0374LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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- Rabbit Anti-CXCR4 Polyclonal Antibody (MRO-1796-CN) (MRO-1796-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Mouse Anti-CXCR4 Recombinant Antibody (HPAB-0329-WJ) (HPAB-0329-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, IHC
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- Mouse Anti-CXCR4 Recombinant Antibody (clone 4C1) (HPAB-0334-WJ)
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- Species Reactivity: Human, Monkey, Mouse
- Type: Mouse IgG
- Application: ELISA, WB
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0685-WJ) (HPAB-0685-WJ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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- Human Anti-CXCR4 Recombinant Antibody (HPAB-0686-WJ) (HPAB-0686-WJ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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- Human Anti-CXCR4 Recombinant Antibody (clone C-9P21) (HPAB-1504-FY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, Inhib
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- Human Anti-CXCR4 Recombinant Antibody (clone B-1M2) (HPAB-1505-FY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, Inhib
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- Human Anti-CXCR4 Recombinant Antibody (clone C-1I24) (HPAB-1506-FY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, Inhib
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- Human Anti-CXCR4 Recombinant Antibody (clone Ab124) (HPAB-1842-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, Inhib
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- Human Anti-CXCR4 Recombinant Antibody (clone C-9P21); Fab Fragment (HPAB-1504-FY-S(P))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Inhib
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- Human Anti-CXCR4 Recombinant Antibody (clone B-1M2); Fab Fragment (HPAB-1505-FY-S(P))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Inhib
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0685-WJ-F(E)) (HPAB-0685-WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0686-WJ-F(E)) (HPAB-0686-WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0687-WJ-F(E)) (HPAB-0687-WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0329-WJ-F(E)) (HPAB-0329-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
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- Mouse Anti-CXCR4 Recombinant Antibody (clone 4C1); Fab Fragment (HPAB-0334-WJ-F(E))
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- Species Reactivity: Human, Monkey, Mouse
- Type: Mouse Fab
- Application: ELISA, WB
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- Human Anti-CXCR4 Recombinant Antibody (clone hz515H7VH1D76NVL2); scFv Fragment (HPAB-0044-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Block, Cyt, FC
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- Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0045-YC-S(P)) (HPAB-0045-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized scFv
- Application: FC, Cyt
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- Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0661-CN-S(P)) (HPAB-0661-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0659-CN-F(E)) (HPAB-0659-CN-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, Neut
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-149MZ-F(E)) (TAB-149MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-143MZ-F(E)) (TAB-143MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: cAMP Assay
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-144MZ-F(E)) (TAB-144MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: cAMP Assay
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-145MZ-F(E)) (TAB-145MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: cAMP Assay
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- Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0659-CN-S(P)) (HPAB-0659-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0660-CN-S(P)) (HPAB-0660-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, Neut
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- Human Anti-CXCR4 Recombinant Antibody (clone hz515H7VH1D76NVL2); Fab Fragment (HPAB-0044-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Block, Cyt, FC
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- Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0045-YC-F(E)) (HPAB-0045-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized Fab
- Application: FC, Cyt
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- Mouse Anti-CXCR4 Recombinant Antibody scFv Fragment (TAB-0012CL-S(P)) (TAB-0012CL-S(P))
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- Application: FC, IHC, Block, Inhib, FuncS
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- Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-0314CL-S(P)) (TAB-0314CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody Fab Fragment (TAB-0012CL-F(E)) (TAB-0012CL-F(E))
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- Application: FC, IHC, Block, Inhib, FuncS
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- Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-0314CL-F(E)) (TAB-0314CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody (TAB-0314CL) (TAB-0314CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Mouse Anti-CXCR4 Recombinant Antibody scFv Fragment (TAB-0011CL-S(P)) (TAB-0011CL-S(P))
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- Application: FC, IHC, Block, Inhib, FuncS
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- Mouse Anti-CXCR4 Recombinant Antibody Fab Fragment (TAB-0011CL-F(E)) (TAB-0011CL-F(E))
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- Application: FC, IHC, Block, Inhib, FuncS
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- Mouse Anti-CXCR4 Recombinant Antibody (TAB-0011CL) (TAB-0011CL)
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- Application: FC, IHC, Block, Inhib, FuncS
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- Mouse Anti-CXCR4 Recombinant Antibody (TAB-0012CL) (TAB-0012CL)
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- Application: Inhib, FC
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- Anti-CXCR4 (A122)-pAcF-MMAF ADC (ADC-095LCT)
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- Target: CXCR4
- Linker: p-acetyl phenylalanine (pAcF)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD184-PEG-S-4FB-dasatinib ADC (ADC-076LZY)
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- Target: CD184
- Linker: PEG-S-4FB linker
- Drug: dasatinib
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- Chicken Anti-CXCR4 Polyclonal IgY (BRD-0152MZ)
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- Species Reactivity: Human, Mouse, Rat, Cow
- Type: Chicken antibody
- Application: WB
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- Anti-CD184-dasatinib ADC (ADC-077LZY)
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- Target: CD184
- Linker: disulfide-cleavable linkers
- Drug: dasatinib
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For Research Use Only. Not For Clinical Use.
Background
C-X-C chemokine receptor 4 (CXCR4) is a G protein-coupled receptor (GPCR) binding the chemokine CXCL12 (SDF-1α). Expressed on hematopoietic stem cells, immune cells, and tumor cells, it regulates cell migration, homing, survival, and proliferation. Overexpressed in multiple cancers (AML, NHL, breast, prostate), CXCR4 promotes tumor metastasis by guiding cells to CXCL12-rich tissues (bone marrow, lungs). It also contributes to chemoresistance and cancer stem cell maintenance. Targeted therapies (plerixafor, monoclonal antibodies) block CXCR4-CXCL12 signaling, inhibiting metastasis and enhancing chemotherapy efficacy, with applications in hematologic and solid tumors.
