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    Recombinant Anti-CXCR4 Biparatopic Antibody, Tandem sdAb

    CAT#: VS-0525-YC1

    The product is a biparatopic antibody composed of two single-domain antibodies (sdAbs) targeting distinct epitopes on the chemokine receptor CXCR4. This biparatopic antibody demonstrates greater affinity than individual sdAbs, inhibiting CXCR4 function and serving as an inverse agonist for CXCR4. It shows potential as a reagent in the study of non-Hodgkin's lymphoma or multiple myeloma (MM).

    Gene Expression
    ❮
    Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)
    ❯

    Specifications

    • Host Animal 1
    • Human
    • Host Animal 2
    • Human
    • Specificity
    • Human CXCR4
    • Species Reactivity
    • Human
    • Type
    • Tandem sdAb
    • Valency
    • 1 + 1
    • Purity
    • >90%
    • Purification
    • Affinity purified
    • Applications
    • ELISA, Inhib
    • Concentration
    • Lot specific
    • Buffer
    • PBS, pH 7.4
    • Preservative
    • No preservatives
    • Storage
    • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
    • Long Name
    • C-X-C Motif Chemokine Receptor 4

    Target

    • Introduction
    • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome.
    • Alternative Names
    • FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E
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    Datasheet

    Datasheet - VS-0525-YC1.pdf

    MSDS

    MSDS - VS-0525-YC1.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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