Anti-Human CXCR4 Recombinant Antibody (515H7) (CAT#: TAB-0012CL)

An anti-CXCR4 antibody capable of inhibiting activation of CXCR4, able to bind specifically to the CXCR4 and having strong anti-tumor activities.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FC

Figure 1 Hz515H7 recognizes human CXCR4, antagonizes SDF-1 binding, and induces a conformational change in CXCR4 homodimers.

Figure 1 Hz515H7 recognizes human CXCR4, antagonizes SDF-1 binding, and induces a conformational change in CXCR4 homodimers.

FACS analysis of viable NIH3T3 (NIH) and NIH3T3-hCXCR4–transfected cells incubated with hz515H7 or an irrelevant hIgG1 mAb. Ab, antibody; MFI, mean fluorescence intensity; WT, wild-type.

Broussas, M., Boute, N., Akla, B., Berger, S., Beau-Larvor, C., Champion, T., ... & Bailly, C. (2016). A new anti-CXCR4 antibody that blocks the CXCR4/SDF-1 axis and mobilizes effector cells. Molecular cancer therapeutics, 15(8), 1890-1899.

Inhib

Figure 1 Hz515H7 inhibits U937 cancer cell migration and Ramos cell proliferation.

Figure 1 Hz515H7 inhibits U937 cancer cell migration and Ramos cell proliferation.

U937 cell migration after incubation in PBS, 10 μg/mL hIgG1 isotype control, or hz515H7 in the presence or absence of SDF-1 (800 ng/mL). RLU, relative luminescence unit. The data shown are the mean and SDs of three independent measurements, each performed in triplicate.

Broussas, M., Boute, N., Akla, B., Berger, S., Beau-Larvor, C., Champion, T., ... & Bailly, C. (2016). A new anti-CXCR4 antibody that blocks the CXCR4/SDF-1 axis and mobilizes effector cells. Molecular cancer therapeutics, 15(8), 1890-1899.


Specifications

  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 515H7
  • Applications
  • Inhib, FC
  • Related Disease
  • Cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Inhibition and Flow Cytometry.

Target

  • Alternative Names
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 515H7"

See other products for "CXCR4"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0152MZ Chicken Anti-CXCR4 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-686CQ Mouse Anti-CXCR4 Recombinant Antibody (clone 44716.111) FC, ICC, IF, IHC-P, Inhib Mouse IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0889 Hi-Affi™ Rabbit Anti-CXCR4 Recombinant Antibody (clone DS889AB) WB, IHC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H72 Afuco™ Anti-CXCR4 ADCC Recombinant Antibody (Ulocuplumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-0012CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare