An anti-CXCR4 antibody capable of inhibiting activation of CXCR4, able to bind specifically to the CXCR4 and having strong anti-tumor activities.
Figure 1 Hz515H7 recognizes human CXCR4, antagonizes SDF-1 binding, and induces a conformational change in CXCR4 homodimers.
FACS analysis of viable NIH3T3 (NIH) and NIH3T3-hCXCR4–transfected cells incubated with hz515H7 or an irrelevant hIgG1 mAb. Ab, antibody; MFI, mean fluorescence intensity; WT, wild-type.
Broussas, M., Boute, N., Akla, B., Berger, S., Beau-Larvor, C., Champion, T., ... & Bailly, C. (2016). A new anti-CXCR4 antibody that blocks the CXCR4/SDF-1 axis and mobilizes effector cells. Molecular cancer therapeutics, 15(8), 1890-1899.
Figure 1 Hz515H7 inhibits U937 cancer cell migration and Ramos cell proliferation.
U937 cell migration after incubation in PBS, 10 μg/mL hIgG1 isotype control, or hz515H7 in the presence or absence of SDF-1 (800 ng/mL). RLU, relative luminescence unit. The data shown are the mean and SDs of three independent measurements, each performed in triplicate.
Broussas, M., Boute, N., Akla, B., Berger, S., Beau-Larvor, C., Champion, T., ... & Bailly, C. (2016). A new anti-CXCR4 antibody that blocks the CXCR4/SDF-1 axis and mobilizes effector cells. Molecular cancer therapeutics, 15(8), 1890-1899.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1224z | Mouse Anti-CXCR4 Recombinant Antibody (clone 12B3) | FC, ICC, IHC, FuncS | Mouse IgG2a |
MOB-2069MZ | Recombinant Mouse Anti-Human CXCR4 Antibody (clone NN0335-8M36) | FC, IHC-Fr, Neut | Mouse antibody |
HPAB-0685-WJ | Human Anti-CXCR4 Recombinant Antibody (HPAB-0685-WJ) | FC | Human IgG |
HPAB-0686-WJ | Human Anti-CXCR4 Recombinant Antibody (HPAB-0686-WJ) | FC | Human IgG |
HPAB-0687-WJ | Human Anti-CXCR4 Recombinant Antibody (HPAB-0687-WJ) | FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0011CL | Anti-Human CXCR4 Recombinant Antibody (414H5) | FC, IHC, Block, Inhib, FuncS | |
TAB-0011CL-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (414H5) | FC, IHC, Block, Inhib, FuncS | |
TAB-0012CL-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (515H7) | FC, IHC, Block, Inhib, FuncS | |
TAB-143MZ | Mouse Anti-CXCR4 Recombinant Antibody (TAB-143MZ) | Cyt, FuncS, Inhib | Mouse lgG1 |
TAB-143MZ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-143MZ-F(E)) | cAMP Assay | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-146MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-146MZ) | Cyt, FuncS, Inhib | Humanized IgG1 |
TAB-147MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-147MZ) | Cyt, FuncS, Inhib | Humanized IgG1 |
TAB-146MZ-F(E) | Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-146MZ-F(E)) | cAMP Assay | Humanized Fab |
TAB-147MZ-F(E) | Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-147MZ-F(E)) | cAMP Assay | Humanized Fab |
TAB-148MZ-F(E) | Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-148MZ-F(E)) | cAMP Assay | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-150MZ-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (CF172) | FC | Human antibody |
TAB-151MZ-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (5C9) | WB, ELISA | Human antibody |
TAB-152MZ-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (5E1) | WB, ELISA | Human antibody |
TAB-153MZ-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (7C8) | WB, ELISA | Human antibody |
TAB-154MZ-S(P) | Anti-Human CXCR4 Recombinant Antibody scFv Fragment (6C7) | WB, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0152MZ | Chicken Anti-CXCR4 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-684CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone 12G5) | FC, CyTOF®, Neut | Mouse IgG2a |
NEUT-685CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone 12G5R) | FC, Neut | Mouse IgG2a |
NEUT-687CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone CBL046) | FC, IHC, Neut | Mouse IgG2 |
NEUT-688CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone CBL470) | FC, CyTOF®, Neut | Mouse IgG2b |
NEUT-689CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone CBL783) | Neut | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-686CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone 44716.111) | FC, ICC, IF, IHC-P, Inhib | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0889 | Hi-Affi™ Rabbit Anti-CXCR4 Recombinant Antibody (clone DS889AB) | WB, IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0044-YC-S(P) | Human Anti-CXCR4 Recombinant Antibody (clone hz515H7VH1D76NVL2); scFv Fragment | Block, Cyt, FC | Humanized scFv |
HPAB-0045-YC-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0045-YC-S(P)) | FC, Cyt | Humanized scFv |
HPAB-1843-FY-F(E) | Human Anti-CXCR4 Recombinant Antibody (clone Ab125); scFv Fragment | Inhib | Human scFv |
HPAB-2065-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-2065-FY-S(P)) | FC, ELISA | Human scFv |
HPAB-2067-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-2067-FY-S(P)) | FC, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H72 | Afuco™ Anti-CXCR4 ADCC Recombinant Antibody (Ulocuplumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0329-WJ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-0329-WJ-F(E)) | ELISA, FC, IHC | Mouse Fab |
HPAB-0334-WJ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody (clone 4C1); Fab Fragment | ELISA, WB | Mouse Fab |
HPAB-0335-WJ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody (clone 6C7); Fab Fragment | ELISA, WB | Mouse Fab |
HPAB-0336-WJ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody (clone 2A4); Fab Fragment | ELISA, WB | Mouse Fab |
HPAB-0337-WJ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody (clone 5C9); Fab Fragment | ELISA, WB | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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