Human Anti-EPHA2 Recombinant Antibody (clone D2-1A7); Fab Fragment (CAT#: HPAB-M0068-YC-F(E))
The antibody D2-1A7 Fab fragment is an internalizing antibody that specifically binds to the tumor associated antigen EphA2. Antibody D2-1A7 was identified as a ligand blocking scFv that is strongly internalized by cells expressing EphA2.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human EPHA2
- Species Reactivity
- Human
- Clone
- D2-1A7
- Applications
- Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase;
- Gene ID
- 1969
- UniProt ID
- P29317
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-083 | Human Anti-EPHA2 Recombinant Antibody (clone 1C1) | ELISA, WB, FuncS | Human IgG |
| HPAB-0429-FY | Human Anti-EPHA2 Recombinant Antibody (HPAB-0429-FY) | FC | Human IgG |
| VS3-XY629 | Mouse Anti-EPHA2 Recombinant Antibody (clone 1B3C7) | ELISA, WB, IHC | Mouse IgG1 |
| VS-0623-WK75 | Human Anti-EPHA2 Recombinant Antibody (clone D2) | ELISA, WB, IF, Block | Human IgG |
| VS-0824-YJ15 | Human Anti-EPHA2 Recombinant Antibody (clone C12) | IA | Human IgG1 kappa |
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