Mouse Anti-FGFR1 Recombinant Antibody (VS3-FY2705)
CAT#: VS3-FY2705
The mouse anti-FGFR1 recombinant monoclonal antibody has been genetically engineered to specifically target FGFR1. The calculated molecular weight of the antigen is 91.9 kDa. It cross-reacts with human and mouse. This monoclonal antibody is potential for conducting research on Chronic renal disease. This monoclonal antibody can be used in Western Blot, Immunohistochemistry, Immunocytochemistry.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077782-FGFR1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Fibroblast growth factor receptor 1 of human and mouse origins
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC, ICC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 91.9 kDa.
- Related Disease
- Chronic renal disease
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Immunocytochemistry: 1/10-1/25
Target
- Alternative Names
- Fibroblast Growth Factor Receptor 1; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; EC 2.7.10.1; BFGF-R-1; FGFR-1; N-SAM; BFGFR; FGFBR; FLT-2; HBGFR; FLT2; CEK; FLG
- Gene ID
- 2260
- UniProt ID
- P11362
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Nucleus
Cytoplasm, cytosol
Cytoplasmic vesicle
- Post Translation Modifications
- Autophosphorylated.
Ubiquitinated.
N-glycosylated in the endoplasmic reticulum.
Glycosylation at Asn227, Asn77, Asn240, Asn264, Asn117, Asn296, Asn317, Asn330, and Asn724
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 10 sites, 10 N-linked glycans (4 sites)
- Protein Refseq
- NP_001167534.1; NP_001167535.1; NP_001167536.1; NP_001167537.1; NP_001167538.1
- Function
- Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.
Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2.
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FGFR1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-283CL | Human Anti-FGFR1 Recombinant Antibody (TAB-283CL) | WB, IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-052WM | Anti-Human FGFR1 Recombinant Antibody (FR1-H7) | ELISA, Neut | Human Antibody |
| TAB-052WM-S(P) | Anti-Human FGFR1 Recombinant Antibody scFv Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-054WM-S(P)) | ELISA | Human scFv |
| TAB-052WM-F(E) | Anti-Human FGFR1 Recombinant Antibody Fab Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-054WM-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-053WM | Mouse Anti-FGFR1 Recombinant Antibody (TAB-053WM) | WB, FC | Mouse IgG |
| TAB-053WM-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-053WM-S(P)) | WB | Mouse scFv |
| TAB-053WM-F(E) | Mouse Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-053WM-F(E)) | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-825CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL537) | WB, Neut | Mouse IgG1 |
| NEUT-826CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone MM0277-6F10) | WB, Neut | Mouse IgG1 |
| NEUT-827CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL059) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1296 | Hi-Affi™ Rabbit Anti-FGFR1 Recombinant Antibody (clone DS1296AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY | Human Anti-FGFR1 Recombinant Antibody (HPAB-0118-FY) | ELISA | Human IgG1 |
| HPAB-N0346-YC | Human Anti-FGFR1 Recombinant Antibody (HPAB-N0346-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-0485LY | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9) | ELISA | Human IgG |
| HPAB-0486LY | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10) | ELISA | Human IgG |
| VS7-HM946 | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL283HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-0118-FY-S(P)) | ELISA | Human scFv |
| HPAB-N0346-YC-S(P) | Human Anti-FGFR1 Recombinant Antibody scFv Fragment (HPAB-N0346-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0485LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); scFv Fragment | ELISA | Human scFv |
| HPAB-0701-FY-F(E) | Human Anti-FGFR1 Recombinant Antibody Fab Fragment (HPAB-0701-FY-F(E)) | ELISA | Human Fab |
| HPAB-3044LY-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-3044LY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (HPAB-0118-FY-F(E)) | ELISA | Human Fab |
| HPAB-N0346-YC-F(E) | Human Anti-FGFR1 Recombinant Antibody Fab Fragment (HPAB-N0346-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0485LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); Fab Fragment | ELISA | Human Fab |
| HPAB-0486LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10); Fab Fragment | ELISA | Human Fab |
| HPAB-0487LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-B1/E12); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY35 | Human Anti-FGFR1 (clone FR1-H7) scFv-Fc Chimera | ELISA, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC333 | Recombinant Anti-FGFR1 Vesicular Antibody, EV Displayed (VS-0425-YC333) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2538 | Anti-FGFR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2539 | Anti-Mouse FGFR1 Immunohistochemistry Kit | IHC |
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