Anti-FLT1 Antibody Prodrug, Protease Activated (18F1)
CAT#: VS-1025-YC70
The Anti-FLT1 Antibody Prodrug, Protease Activated (18F1) is an antibody prodrug comprised of a recombinant human antibody targeting human FLT1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FLT1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FLT1 effectively. FLT1 (FMS-like tyrosine kinase 1), or VEGFR1, is a receptor for VEGF that plays a more prominent role in recruiting immune cells and modulating the tumor microenvironment than in directly driving endothelial cell proliferation. Its expression on both endothelial cells and macrophages/myeloid cells influences inflammation and blood vessel stabilization in tumors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/90_G3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/1368_A5_2_blue_green.jpg
Normal Tissue
Figure 3 Testis
Peritubular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/142518_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HMC-1, HUVEC TERT2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FLT1
- Target
- FLT1
- Species Reactivity
- Human
- Isotype
- IgG
- Clone
- 18F1
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
- Alternative Names
- EC 2.7.10.1; VEGFR-1; VEGFR1; FLT-1; FLT
- Gene ID
- 2321
- UniProt ID
- P17948
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Related Diseases
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 18F1"
- CAT
- Product Name
See other products for "FLT1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1152 | Human Anti-FLT1 Recombinant Antibody (clone 867.2A3); scFv Fragment | ELISA, WB, IHC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1158 | Human Anti-FLT1 Recombinant Antibody (clone 867.2D2); scFv Fragment, HRP | ELISA, WB, IHC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177 | Anti-Human VEGFR-1 Recombinant Antibody (TAB-177) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008CQ | Mouse Anti-FLT1 Recombinant Antibody (TAB-008CQ) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ | Human Anti-FLT1 Recombinant Antibody (TAB-009CQ) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-008CQ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-009CQ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008CQ-F(E) | Mouse Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-008CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-009CQ-F(E)) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2200CT | Recombinant Mouse anti-Human FLT1 Monoclonal antibody (EML763) | BL, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-845CQ | Mouse Anti-FLT1 Recombinant Antibody (clone MAB0702) | WB, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1322 | Hi-Affi™ Rabbit Anti-FLT1 Recombinant Antibody (clone DS1322AB) | WB, IHC-P, ICC, IF, IP, ELISA, IHC-P, IHC-Fr | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0137-YC | Human Anti-FLT1 Recombinant Antibody (clone 18F1) | ELISA, FC, Block, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0137-YC-S(P) | Human Anti-FLT1 Recombinant Antibody (clone 18F1); scFv Fragment | ELISA, FC, Block, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0137-YC-F(E) | Human Anti-FLT1 Recombinant Antibody (clone 18F1); Fab Fragment | ELISA, FC, Block, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527) | ELISA, FC | Mouse IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1606LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1606LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1606LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1606LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1607LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1607LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1606LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1606LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1607LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1607LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1609LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1609LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-177 | Afuco™ Anti-FLT1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-177) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0673 | PE-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0674 | APC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0675 | FITC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0676 | A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1412 | PE-A*24:02/Human FLT1 (SYGVLLWEI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY850 | Anti-FLT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY53 | Mouse Anti-FLT1 scFv-Fc Chimera (VS-0425-FY53) | WB, ELISA, Inhib | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC224 | Recombinant Anti-FLT1 Vesicular Antibody, EV Displayed (VS-0425-YC224) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2581 | Anti-Mouse FLT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2582 | Anti-Zebrafish FLT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2580 | Anti-Human FLT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC135 | SmartAb™ Recombinant Anti-FLT1 pH-dependent Antibody (Clone 15F11) | ELISA, WB | Human IgG1 |
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