Mouse Anti-FLT1 scFv-Fc Chimera (VS-0425-FY53) (CAT#: VS-0425-FY53)

• Immunogen
• The antibody was obtained by immunizing BALB/c mice with a peptide, A4, which was derived from the sequence of VEGFR-1. This peptide was crucial in eliciting an immune response, leading to the production of specific antibodies targeting the VEGFR-1 receptor.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• The antibody specifically binds to the extracellular domain of VEGFR-1.

• Species Reactivity
• Human

• Applications
• Western Blot, ELISA, Inhibition

• Related Disease
• Non-small cell lung cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 10 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Fms Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); Vascular Endothelial Growth Factor Receptor 1; Tyrosine-Protein Kinase Receptor FLT; Tyrosine-Protein Kinase FRT; Fms-Like Tyrosine Kinase 1; EC 2.7.10.1;

• Gene ID
• 2321

• UniProt ID
• P17948

• Long Name
• Fms Related Tyrosine Kinase 1

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein; Endosome

• Post Translation Modifications
• N-glycosylated.
  Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
  Autophosphorylated on tyrosine residues upon ligand binding.

• Protein Refseq
• NP_001153392.1; NP_001153502.1; NP_001153503.1; NP_002010.2

• Function
• Acts as a positive regulator of postnatal retinal hyaloid vessel regression.
  May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
  Can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
  Its function in promoting cell proliferation seems to be cell-type specific.
  Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
  Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
  Modulates KDR signaling by forming heterodimers with KDR.
  Ligand binding leads to the activation of several signaling cascades.
  Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.

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