Human Anti-FLT1 Recombinant Antibody (clone 18F1) (CAT#: HPAB-0137-YC)
The antibodies are specific for vascular endothelial growth factor receptor-1 (VEGFR-I) and methods of treating angiogenesis-associated diseases and tumors with antibodies to VEGFR-I.
Specific Inquiry
FuncS
Figure 1 VEGF-A or -B enhances CRC cell migration
Effect of VEGF-A or -B on CRC cell migration.(a) HT-29 cells were treated with the anti-VEGFR-1 antibody 18F1 and used for transwell migration assays. At 48 h, incubation with VEGF-A or -B significantly increased cell migration, but treatment with the VEGFR-1 antibody blocked this effect. *P<0.0001 vs control cells; bars indicate s.e.m. Similar results were observed in SW480 cells (data not shown).(b) Photographs of migrated cells
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
FuncS
Figure 2 VEGF-A or -B enhances CRC cell invasion
Effect of VEGF-A or -B on CRC cell invasion. (a) SW480 cells were treated with the anti-VEGFR-1 antibody 18F1 and transwell invasion assays were performed. At 48 h, incubation with VEGF-A or -B increased cell invasion, but treatment with the VEGFR-1 antibody completely blocked this effect. *P<0.05 vs control cells; bars indicate s.e.m. (b) Photographs of invaded cells
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
FuncS
Figure 3 VEGF-A or VEGF-B enhances CRC cell growth in soft agar
Effect of VEGF-A or -B on colony formation in soft agar.(a) HT29 cells were plated in soft agar with or without VEGF-A, -B, or VEGFR-1 antibody (18F1), and colonies were counted 14 days later. Cells treated with VEGF-A or -B formed more and larger colonies than controls; addition of VEGFR-1 antibody decreased colony formation induced by the VEGF ligands. *P<0.03 vs control cells; bars indicate s.e.m.(b) Photographs of colony formation.
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human FLT1
- Species Reactivity
- Human
- Clone
- 18F1
- Applications
- ELISA, FC, Block, WB
- Related Disease
- Angiogenic-related disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Fms Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); Tyrosine-Protein Kinase Receptor FLT; Fms-Related Tyrosine Kinase 1; Tyrosine-Protein Kinase FRT; ms-Like Tyrosine Kinase 1; EC 2.7.10.1; VEGFR-1; VEGFR1; FLT-1; FLT; Vascular Endothelial Growth Factor Receptor 1; EC 2.7.10; FRT
- Gene ID
- 2321
- UniProt ID
- P17948
Related Resources
Rheumatoid Arthritis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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