Anti-FLT1 (clone 18F1) Recombinant Antibody Coupled Liposome (VS-1024-FY97)
CAT#: VS-1024-FY97
The application of anti-FLT1 antibody-conjugated liposomes in glioma may provide a more targeted treatment option. By targeting the FLT1 protein, this therapeutic approach can enhance the accumulation of drugs at the tumor site, thereby improving efficacy. Future clinical trials will help verify its safety and effectiveness, bringing new hope to glioma patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/90_G3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/1368_A5_2_blue_green.jpg
Normal Tissue
Figure 3 Testis
Peritubular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/142518_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HMC-1, HUVEC TERT2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- 18F1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was designed to selectively bind to the human FLT1 (Fms-like tyrosine kinase 1) receptor. FLT1 is primarily involved in the regulation of angiogenesis and vasculogenesis, playing a crucial role in the development of blood vessels. By specifically targeting FLT1, this monoclonal antibody can potentially inhibit excessive vascular growth and contribute to therapeutic strategies for various diseases characterized by abnormal blood vessel formation, such as cancer and inflammatory disorders.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FLT1
- Introduction
- This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
- Alternative Names
- Fms Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); Vascular Endothelial Growth Factor Receptor 1; Tyrosine-Protein Kinase Receptor FLT; Tyrosine-Protein Kinase FRT; Fms-Like Tyrosine Kinase 1
- Full Name
- Fms Related Tyrosine Kinase 1
- Gene ID
- 2321
- UniProt ID
- P17948
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Endosome
- Post Translation Modifications
- N-glycosylated.
Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
Autophosphorylated on tyrosine residues upon ligand binding.
- Protein Refseq
- NP_001153392.1; NP_001153502.1; NP_001153503.1; NP_002010.2
- Function
- Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity).
May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
Can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
Its function in promoting cell proliferation seems to be cell-type specific.
Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
Modulates KDR signaling by forming heterodimers with KDR.
Ligand binding leads to the activation of several signaling cascades.
Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.
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Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 18F1"
- CAT
- Product Name
See other products for "FLT1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1152 | Human Anti-FLT1 Recombinant Antibody (clone 867.2A3); scFv Fragment | ELISA, WB, IHC, IP | Human scFv |
| DrMAB-1158 | Human Anti-FLT1 Recombinant Antibody (clone 867.2D2); scFv Fragment, HRP | ELISA, WB, IHC, IP | Human scFv |
| HPAB-0785-CN-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1606LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1606LY-S(P)) | ELISA | Human scFv |
| HPAB-1607LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1607LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177 | Anti-Human VEGFR-1 Recombinant Antibody (TAB-177) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008CQ | Mouse Anti-FLT1 Recombinant Antibody (TAB-008CQ) | ELISA, FC | Mouse IgG |
| TAB-008CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-008CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-008CQ-F(E) | Mouse Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-008CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ | Human Anti-FLT1 Recombinant Antibody (TAB-009CQ) | ELISA | Chimeric antibody (mouse/human) |
| TAB-009CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-009CQ-S(P)) | ELISA | Mouse scFv |
| TAB-009CQ-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-009CQ-F(E)) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-845CQ | Mouse Anti-FLT1 Recombinant Antibody (clone MAB0702) | WB, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1322 | Hi-Affi™ Rabbit Anti-FLT1 Recombinant Antibody (clone DS1322AB) | WB, IHC-P, ICC, IF, IP, ELISA, IHC-P, IHC-Fr | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-1606LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1606LY-F(E)) | ELISA | Human Fab |
| HPAB-1607LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1607LY-F(E)) | ELISA | Human Fab |
| HPAB-1609LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1609LY-F(E)) | ELISA | Human Fab |
| HPAB-0065-YJ-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone 6.12); Fab Fragment | Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1606LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1606LY) | ELISA | Human IgG |
| HPAB-1607LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1607LY) | ELISA | Human IgG |
| HPAB-1609LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1609LY) | ELISA | Human IgG |
| HPAB-1610LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1610LY) | ELISA | Human IgG |
| HPAB-1611LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1611LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-177 | Afuco™ Anti-FLT1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-177) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0673 | PE-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0674 | APC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0675 | FITC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN1412 | PE-A*24:02/Human FLT1 (SYGVLLWEI) MHC Tetramer | FCM | |
| MHC-YF771 | A*02:01/Human VEGFR1 (GVLLWEIFSL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY850 | Anti-FLT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2581 | Anti-Mouse FLT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2582 | Anti-Zebrafish FLT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2580 | Anti-Human FLT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY53 | Mouse Anti-FLT1 scFv-Fc Chimera (VS-0425-FY53) | WB, ELISA, Inhib | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC224 | Recombinant Anti-FLT1 Vesicular Antibody, EV Displayed (VS-0425-YC224) | ELISA, FC, Neut, Cell-uptake |
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