Anti-FLT1 (clone 18F1) Recombinant Antibody Coupled Liposome (VS-1024-FY97) (CAT#: VS-1024-FY97)

• Potential Clinical Applications
• Glioma

• Clone
• 18F1

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that was designed to selectively bind to the human FLT1 (Fms-like tyrosine kinase 1) receptor. FLT1 is primarily involved in the regulation of angiogenesis and vasculogenesis, playing a crucial role in the development of blood vessels. By specifically targeting FLT1, this monoclonal antibody can potentially inhibit excessive vascular growth and contribute to therapeutic strategies for various diseases characterized by abnormal blood vessel formation, such as cancer and inflammatory disorders.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FLT1

• Introduction
• This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

• Alternative Names
• Fms Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); Vascular Endothelial Growth Factor Receptor 1; Tyrosine-Protein Kinase Receptor FLT; Tyrosine-Protein Kinase FRT; Fms-Like Tyrosine Kinase 1

• Full Name
• Fms Related Tyrosine Kinase 1

• Gene ID
• 2321

• UniProt ID
• P17948

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein
  Endosome

• Post Translation Modifications
• N-glycosylated.
  Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
  Autophosphorylated on tyrosine residues upon ligand binding.

• Protein Refseq
• NP_001153392.1; NP_001153502.1; NP_001153503.1; NP_002010.2

• Function
• Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity).
  May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
  Can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
  Its function in promoting cell proliferation seems to be cell-type specific.
  Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
  Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
  Modulates KDR signaling by forming heterodimers with KDR.
  Ligand binding leads to the activation of several signaling cascades.
  Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.

• HPAB-0137-YC
• Human Anti-FLT1 Recombinant Antibody (clone 18F1)

• HPAB-0137-YC-S(P)
• Human Anti-FLT1 Recombinant Antibody (clone 18F1); scFv Fragment

• HPAB-0137-YC-F(E)
• Human Anti-FLT1 Recombinant Antibody (clone 18F1); Fab Fragment

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