Human Anti-GAPDH Recombinant Antibody (clone lesion); Fab Fragment
CAT#: FAMAB-0117-YC-F(E)
GAPDH is glycolytic enzymes essential for efficient energy production and are expressed in all prokaryotic and eukaryotic organisms. In addition to its glycolytic functions, GAPDH is a multifunctional protein endowed with diverse activities, including phosphorylating transverse-tubule proteins, stimulating RNA transcription, and influencing DNA replication and DNA repair. TPI and GAPDH have been considered to associate with brain microtubules. Anti-TPI or anti-GAPDH Abs may induce an immune hypersensitivity reaction, through activation of complements and macrophages, leading to neuronal and axonal degeneration in MS.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40067/752_B3_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach
Immunohistochemical staining of human stomach, lower shows strong nuclear and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40067/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human skin
Immunohistochemical staining of human skin shows strong nuclear positivity in keratinocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_B_8_1_selected.jpg
Normal Tissue
Figure 5 IHC staining of human kidney
Immunohistochemical staining of human kidney shows cytoplasmic and nuclear positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5197/ihc_selected.jpg
Normal Tissue
Figure 6 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong nuclear positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79968/170623_B_3_6_selected.jpg
Subcellular Location
Figure 7 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40067/1874_F7_61_blue_red_green.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_A_8_3.jpg
Normal Tissue
Figure 9 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_A_8_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Proximal tubules (cell body)
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_A_7_5.jpg
Normal Tissue
Figure 11 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_A_4_6.jpg
Normal Tissue
Figure 12 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61280/169039_A_7_8.jpg
RNA Expression
Figure 13 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111640-GAPDH
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Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human GAPDH
- Species Reactivity
- Human
- Clone
- lesion
- Applications
- ELISA, WB
- Related Disease
- Multiple sclerosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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Lot Number:
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|---|---|---|---|
| MOB-386-F(E) | Recombinant Anti-human GAPDH Antibody Fab Fragment | IP, RIA, FuncS | Fab |
| MHH-386-F(E) | Recombinant Human Anti-human GAPDH Antibody Fab Fragment | ELISA, WB, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-386-S(P) | Recombinant Human Anti-human GAPDH Antibody scFv Fragment | WB, FC, FuncS | scFv |
| FAMAB-0117-YC-S(P) | Human Anti-GAPDH Recombinant Antibody (clone lesion); scFv Fragment | ELISA, WB | Human scFv |
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| CAT | Product Name | Application | Type |
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| MOR-1398 | Hi-Affi™ Rabbit Anti-GAPDH Recombinant Antibody (clone DS1398AB) | WB, ICC, IP, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
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| MRO-0632-CN | Mouse Anti-GAPDH Recombinant Antibody (clone 5-E10) | WB, IF | Mouse IgM |
| CAT | Product Name | Application | Type |
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| MRO-0202YJ | Mouse Anti-GAPDH Polyclonal Antibody | WB, ELISA | Mouse IgG |
| ZG-0839F | Mouse Anti-GAPDH Recombinant Antibody (clone GA1R) | IHC, WB, DB, ELISA | Mouse IgG1 |
| VS3-XY760 | Mouse Anti-GAPDH Recombinant Antibody, HRP (clone 2B8) | WB | |
| VS7-HM990 | Mouse Anti-GAPDH Recombinant Antibody (clone CBL309HM) | WB, IHC-p, IF, ICC, ELISA | Mouse IgG |
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| CAT | Product Name | Application | Type |
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| VS-0424-XY108 | AbPlus™ Anti-GAPDH Magnetic Beads (VS-0424-XY108) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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| VS-1024-XY212 | Mouse Anti-NHP GAPDH Recombinant Antibody (clone 1D4) | WB, IF | Mouse IgM |
| CAT | Product Name | Application | Type |
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| VS-0125-FY39 | Mouse Anti-GAPDH (clone W25lesion) scFv-Fc Chimera | ELISA, WB | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-1224-YC534 | DrugMonitor™ Anti-GAPDH Antibody (VS-1224-YC534) | ELISA, PK/PD, ADA control | Mouse IgG |
| CAT | Product Name | Application | Type |
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| VS-0325-XY896 | Anti-GAPDH Immunohistochemistry Kit | IHC | |
| VS-0525-XY2729 | Anti-Mouse GAPDH Immunohistochemistry Kit | IHC | |
| VS-0525-XY2728 | Anti-Human GAPDH Immunohistochemistry Kit | IHC | |
| VS-0525-XY2730 | Anti-Goat GAPDH Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC435 | CytoStream™ Rabbit Anti-GAPDH Recombinant Antibody (VS13-YC435) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
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