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    GAPDH

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    • Mouse Anti-GAPDH Polyclonal Antibody (MRO-0202YJ)
      • Species Reactivity: Human, Mouse, Rat, Pig, Zebrafish, Bovine, Sheep, Rabbit, Goat, Guinea pig, Dog, Monkey, Hamster, Chicken, Plants, Rice, Fish
      • Type: Mouse IgG
      • Application: WB, ELISA
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    • Mouse Anti-GAPDH Recombinant Antibody (VS-0725-YC91)
      • Species Reactivity: Human, Mouse, Rat, Cat, Chicken, Dog, Fish, Monkey, Pig, Rabbit, X.laevis, Zebrafish
      • Type: Mouse IgG
      • Application: ELISA, ICC, IF, IHC, WB
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Protein class

    Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Extravillous trophoblasts)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    Homotetramer (PubMed:16239728, 16510976). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation (By similarity). Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation (By similarity). Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules (By similarity). Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1 (PubMed:11724794, 16501887, 15628863, 20644585). Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:22771119). Component of the GAIT complex (PubMed:15479637). Interacts with FKBP6; leading to inhibit GAPDH catalytic activity (PubMed:19001379). Interacts with TRAF2, promoting TRAF2 ubiquitination (PubMed:23332158). Interacts with TRAF3, promoting TRAF3 ubiquitination (PubMed:27387501).

    Molecular function

    Oxidoreductase, Transferase

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