Recombinant Mouse Anti-HA Antibody (AF4H1K1)
CAT#: HPAB-N0122-YC
The antibody can well neutralize H3N2, H4N6 and H14N5 subtype influenza viruses, combine HA proteins of all subtype influenza viruses in a group 2, neutralize H3-subclade viruses and inhibit copying of the H3 subtype influenza viruses in a mouse body and has the important economic and social significance.
Published Data
FuncS
Figure 1 AF4H1K1 showed prophylactic and therapeutic activities against H3 and H7 IAVs.
a–d Prophylactic and therapeutic efficacies of AF4H1K1 against H3-rAC/68. In the H3-infected experiments, BALB/c mice were intravenously administrated with 15 mg/kg of AF4H1K1 via tail veil 1 day before, or 4, 24, and 48 hours (hrs) after being challenged with 100 MID₅₀ (15 mice per group). Anti-Ebola MAb 13C6-treated mice were used as a control. Lung tissues were collected, homogenized for the virus titration at 3 dpi (a, c) and 5 dpi (b, d), respectively. AF4H1K1 could reduce the virus replication in the lung of virus-infected mice in both preexposure prophylactic evaluation (a, b) and therapeutic assessment tests (c, d) according to the unpaired t-tests (n = 5) using GraphPad Prism 5 software. *P < 0.05, **P < 0.01, ***P < 0.001. They are one representative experiment out of three. e–h Evaluation of prophylactic and therapeutic efficacies of AF4H1K1 against H7N9 HPAIV. In the H7N9 IAV-challenged experiments, BALB/c mice were intravenously administrated with 15 mg/kg of AF4H1K1 via tail veil at 1 day before or after virus challenge with 10⁵ 50% of lethal dose (LD₅₀) (equally to 10⁷ 50% egg infective dose (EID₅₀)). AF4H1K1 and AF4H1/FI6v3L were fully protective against the lethality when being administrated at 24 h before (e) and after (f) virus challenge, but could not prevent the body weight from dropping in both prophylactic (g) and therapeutic (h) experiments. n = 5. They are one representative experiment out of two, which have been done in Biosafety level 3 laboratory. Survival analysis was carried out by Kaplan–Meier method using GraphPad Prism 5 software
Xiao, H., Guo, T., Yang, M., Qi, J., Huang, C., Hong, Y.,... & McCauley, J. (2019). Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses. Cell discovery, 5(1), 21.
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Influenza Virus
- Species Reactivity
- Influenza Virus
- Clone
- AF4H1K1
- Applications
- IF, Neut, FuncS
- Related Disease
- Influenza Virus Infection
Applications
- Application Notes
- The antibody was validated for Immunofluorescence, Neutralization, and Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- Hemagglutinin
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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